Roger L Williams
Roger L Williams
Group leader, Medical Research Council, Laboratory of Molecular Biology
Potvrđena adresa e-pošte na - Početna stranica
Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition)1
DJ Klionsky, AK Abdel-Aziz, S Abdelfatah, M Abdellatif, A Abdoli, S Abel, ...
autophagy 17 (1), 1-382, 2021
Structural determinants of phosphoinositide 3-kinase inhibition by wortmannin, LY294002, quercetin, myricetin, and staurosporine
EH Walker, ME Pacold, O Perisic, L Stephens, PT Hawkins, MP Wymann, ...
Molecular cell 6 (4), 909-919, 2000
Crystal structure of human immunodeficiency virus type 1 reverse transcriptase complexed with double-stranded DNA at 3.0 A resolution shows bent DNA.
A Jacobo-Molina, J Ding, RG Nanni, AD Clark Jr, X Lu, C Tantillo, ...
Proceedings of the National Academy of Sciences 90 (13), 6320-6324, 1993
A pharmacological map of the PI3-K family defines a role for p110α in insulin signaling
ZA Knight, B Gonzalez, ME Feldman, ER Zunder, DD Goldenberg, ...
Cell 125 (4), 733-747, 2006
The emerging shape of the ESCRT machinery
RL Williams, S Urbé
Nature reviews Molecular cell biology 8 (5), 355-368, 2007
Crystal structure and functional analysis of Ras binding to its effector phosphoinositide 3-kinase γ
ME Pacold, S Suire, O Perisic, S Lara-Gonzalez, CT Davis, EH Walker, ...
Cell 103 (6), 931-944, 2000
Crystal structure of a mammalian phosphoinositide-specific phospholipase Cδ
LO Essen, O Perisic, R Cheung, M Katan, RL Williams
Nature 380 (6575), 595-602, 1996
Phosphoinositide 3-kinase δ gene mutation predisposes to respiratory infection and airway damage
I Angulo, O Vadas, F Garçon, E Banham-Hall, V Plagnol, TR Leahy, ...
Science 342 (6160), 866-871, 2013
Structural insights into phosphoinositide 3-kinase catalysis and signalling
EH Walker, O Perisic, C Ried, L Stephens, RL Williams
Nature 402 (6759), 313-320, 1999
Targeted polypharmacology: discovery of dual inhibitors of tyrosine and phosphoinositide kinases
B Apsel, JA Blair, B Gonzalez, TM Nazif, ME Feldman, B Aizenstein, ...
Nature chemical biology 4 (11), 691, 2008
Mechanism of two classes of cancer mutations in the phosphoinositide 3-kinase catalytic subunit
N Miled, Y Yan, WC Hon, O Perisic, M Zvelebil, Y Inbar, ...
science 317 (5835), 239-242, 2007
Binding of the PX domain of p47phox to phosphatidylinositol 3, 4‐bisphosphate and phosphatidic acid is masked by an intramolecular interaction
D Karathanassis, RV Stahelin, J Bravo, O Perisic, CM Pacold, W Cho, ...
The EMBO journal, 2002
A role for the ESCRT system in cell division in archaea
RY Samson, T Obita, SM Freund, RL Williams, SD Bell
Science 322 (5908), 1710-1713, 2008
The p110δ structure: mechanisms for selectivity and potency of new PI (3) K inhibitors
A Berndt, S Miller, O Williams, DD Le, BT Houseman, JI Pacold, F Gorrec, ...
Nature chemical biology 6 (2), 117-124, 2010
The crystal structure of the PX domain from p40phox bound to phosphatidylinositol 3-phosphate
J Bravo, D Karathanassis, CM Pacold, ME Pacold, CD Ellson, ...
Molecular cell 8 (4), 829-839, 2001
Crystal structure of a calcium-phospholipid binding domain from cytosolic phospholipase A2
O Perisic, S Fong, DE Lynch, M Bycroft, RL Williams
Journal of Biological Chemistry 273 (3), 1596-1604, 1998
Structural basis for selective recognition of ESCRT-III by the AAA ATPase Vps4
T Obita, S Saksena, S Ghazi-Tabatabai, DJ Gill, O Perisic, SD Emr, ...
Nature 449 (7163), 735-739, 2007
Structural basis for activation and inhibition of class I phosphoinositide 3-kinases
O Vadas, JE Burke, X Zhang, A Berndt, RL Williams
Science signaling 4 (195), re2-re2, 2011
ESCRT-I core and ESCRT-II GLUE domain structures reveal role for GLUE in linking to ESCRT-I and membranes
H Teo, DJ Gill, J Sun, O Perisic, DB Veprintsev, Y Vallis, SD Emr, ...
Cell 125 (1), 99-111, 2006
Oncogenic mutations mimic and enhance dynamic events in the natural activation of phosphoinositide 3-kinase p110α (PIK3CA)
JE Burke, O Perisic, GR Masson, O Vadas, RL Williams
Proceedings of the National Academy of Sciences 109 (38), 15259-15264, 2012
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