| CEP-1347/KT-7515, an inhibitor of c-jun N-terminal kinase activation, attenuates the 1-methyl-4-phenyl tetrahydropyridine-mediated loss of nigrostriatal dopaminergic neurons in … MS Saporito, EM Brown, MS Miller, S Carswell Journal of Pharmacology and Experimental Therapeutics 288 (2), 421-427, 1999 | 346 | 1999 |
| MPTP Activates c‐Jun NH2‐Terminal Kinase (JNK) and Its Upstream Regulatory Kinase MKK4 in Nigrostriatal Neurons In Vivo MS Saporito, BA Thomas, RW Scott Journal of neurochemistry 75 (3), 1200-1208, 2000 | 315 | 2000 |
| 2 discovery of Cep-1347/Kt-7515, an inhibitor of the Jnk/Sapk pathway for the treatment of neurodegenerative diseases MS Saporito, RL Hudkins, AC Maroney Progress in medicinal chemistry 40, 23-62, 2002 | 143 | 2002 |
| ABHD6 blockade exerts antiepileptic activity in PTZ-induced seizures and in spontaneous seizures in R6/2 mice AV Naydenov, EA Horne, CS Cheah, K Swinney, KL Hsu, JK Cao, ... Neuron 83 (2), 361-371, 2014 | 121 | 2014 |
| Mixed lineage kinase activity of indolocarbazole analogues C Murakata, M Kaneko, G Gessner, TS Angeles, MA Ator, TM O'Kane, ... Bioorganic & medicinal chemistry letters 12 (2), 147-150, 2002 | 110 | 2002 |
| Chronic 1, 25-dihydroxyvitamin D3-mediated induction of nerve growth factor mRNA and protein in L929 fibroblasts and in adult rat brain MS Saporito, ER Brown, KC Hartpence, HM Wilcox, JL Vaught, ... Brain research 633 (1-2), 189-196, 1994 | 104 | 1994 |
| Targeting the JNK pathway for therapeutic benefit in CNS disease D Bozyczko-Coyne, MS Saporito, RL Hudkins Current Drug Targets-CNS & Neurological Disorders 1 (1), 31-49, 2002 | 94 | 2002 |
| Pharmacological induction of nerve growth factor mRNA in adult rat brain MS Saporito, HM Wilcox, KC Hartpence, ME Lewis, JL Vaught, S Carswell Experimental neurology 123 (2), 295-302, 1993 | 94 | 1993 |
| Inhibition of mixed lineage kinase 3 attenuates MPP+-induced neurotoxicity in SH-SY5Y cells JR Mathiasen, BAW McKenna, MS Saporito, GD Ghadge, RP Roos, ... Brain research 1003 (1-2), 86-97, 2004 | 65 | 2004 |
| Dopaminergic neurotoxicity of 1-methyl-4-phenylpyridinium analogs in cultured neurons: relationship to the dopamine uptake system and inhibition of mitochondrial respiration. MS Saporito, RE Heikkila, SK Youngster, WJ Nicklas, HM Geller Journal of Pharmacology and Experimental Therapeutics 260 (3), 1400-1409, 1992 | 60 | 1992 |
| MLR-1023 is a potent and selective allosteric activator of Lyn kinase in vitro that improves glucose tolerance in vivo MS Saporito, AR Ochman, CA Lipinski, JA Handler, AG Reaume Journal of Pharmacology and Experimental Therapeutics 342 (1), 15-22, 2012 | 55 | 2012 |
| Preservation of cholinergic activity and prevention of neuron death by CEP-1347/KT-7515 following excitotoxic injury of the nucleus basalis magnocellularis MS Saporito, ER Brown, S Carswell, AM DiCamillo, MS Miller, C Murakata, ... Neuroscience 86 (2), 461-471, 1998 | 52 | 1998 |
| The Lyn kinase activator MLR-1023 is a novel insulin receptor potentiator that elicits a rapid-onset and durable improvement in glucose homeostasis in animal models of type 2 … AR Ochman, CA Lipinski, JA Handler, AG Reaume, MS Saporito Journal of Pharmacology and Experimental Therapeutics 342 (1), 23-32, 2012 | 49 | 2012 |
| CEP-11004, an inhibitor of the SAPK/JNK pathway, reduces TNF-α release from lipopolysaccharide-treated cells and mice JR Ciallella, M Saporito, S Lund, M Leist, H Hasseldam, N McGann, ... European journal of pharmacology 515 (1-3), 179-187, 2005 | 47 | 2005 |
| 1‐Methyl‐4‐(2′‐ethylphenyl)‐1, 2, 3, 6‐tetrahydropyridine‐induced toxicity in PC12 cells is enhanced by preventing glycolysis AN Basma, RE Heikkila, MS Saporito, M Philbert, HM Geller, WJ Nicklas Journal of neurochemistry 58 (3), 1052-1059, 1992 | 44 | 1992 |
| Mixed-lineage kinase 1 and mixed-lineage kinase 3 subtype-selective dihydronaphthyl [3, 4-a] pyrrolo [3, 4-c] carbazole-5-ones: optimization, mixed-lineage kinase 1 … RL Hudkins, JL Diebold, M Tao, KA Josef, CH Park, TS Angeles, ... Journal of medicinal chemistry 51 (18), 5680-5689, 2008 | 43 | 2008 |
| Intravenously administered ganaxolone blocks diazepam-resistant lithium-pilocarpine–induced status epilepticus in rats: comparison with allopregnanolone MS Saporito, JA Gruner, A DiCamillo, R Hinchliffe, M Barker-Haliski, ... Journal of Pharmacology and Experimental Therapeutics 368 (3), 326-337, 2019 | 40 | 2019 |
| Systemic dexamethasone administration increases septal Trk autophosphorylation in adult rats via an induction of nerve growth factor. MS Saporito, ER Brown, KC Hartpence, HM Wilcox, E Robbins, JL Vaught, ... Molecular pharmacology 45 (3), 395-401, 1994 | 39 | 1994 |
| High levels of synthesis and local effects of nerve growth factor in the septal region of the adult rat brain MS Saporito, S Carswell Journal of Neuroscience 15 (3), 2280-2286, 1995 | 37 | 1995 |
| Synthesis and Pharmacological Evaluation of N-(3-(1H-Indol-4-yl)-5-(2-methoxyisonicotinoyl)phenyl)methanesulfonamide (LP-261), a Potent Antimitotic Agent RS Shetty, Y Lee, B Liu, A Husain, RW Joseph, Y Lu, D Nelson, J Mihelcic, ... Journal of medicinal chemistry 54 (1), 179-200, 2011 | 35 | 2011 |
