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Derek Narendra, MD, PhD
Derek Narendra, MD, PhD
Lasker Clinical Research Scholar and Tenure Track Investigator, NINDS, NIH
Verified email at nih.gov
Title
Cited by
Cited by
Year
Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition)1
DJ Klionsky, AK Abdel-Aziz, S Abdelfatah, M Abdellatif, A Abdoli, S Abel, ...
autophagy 17 (1), 1-382, 2021
13460*2021
Parkin is recruited selectively to impaired mitochondria and promotes their autophagy
D Narendra, A Tanaka, DF Suen, RJ Youle
The Journal of cell biology 183 (5), 795-803, 2008
41622008
Mechanisms of mitophagy
RJ Youle, DP Narendra
Nature reviews Molecular cell biology 12 (1), 9-14, 2011
34172011
PINK1 is selectively stabilized on impaired mitochondria to activate Parkin
DP Narendra, SM Jin, A Tanaka, DF Suen, CA Gautier, J Shen, ...
PLoS biology 8 (1), e1000298, 2010
29642010
Identification of novel risk loci, causal insights, and heritable risk for Parkinson's disease: a meta-analysis of genome-wide association studies
MA Nalls, C Blauwendraat, CL Vallerga, K Heilbron, S Bandres-Ciga, ...
The Lancet Neurology 18 (12), 1091-1102, 2019
15412019
Proteasome and p97 mediate mitophagy and degradation of mitofusins induced by Parkin
A Tanaka, MM Cleland, S Xu, DP Narendra, DF Suen, M Karbowski, ...
Journal of Cell Biology 191 (7), 1367-1380, 2010
14412010
Mitochondrial membrane potential regulates PINK1 import and proteolytic destabilization by PARL
SM Jin, M Lazarou, C Wang, LA Kane, DP Narendra, RJ Youle
Journal of Cell Biology 191 (5), 933-942, 2010
13652010
Parkin and PINK1 mitigate STING-induced inflammation
DA Sliter, J Martinez, L Hao, XI Chen, N Sun, TD Fischer, JL Burman, Y Li, ...
Nature 561 (7722), 258-262, 2018
10312018
p62/SQSTM1 is required for Parkin-induced mitochondrial clustering but not mitophagy; VDAC1 is dispensable for both
D Narendra, LA Kane, DN Hauser, IM Fearnley, RJ Youle
Autophagy 6 (8), 1090-1106, 2010
8422010
Targeting mitochondrial dysfunction: role for PINK1 and Parkin in mitochondrial quality control
DP Narendra, RJ Youle
Antioxidants & redox signaling 14 (10), 1929-1938, 2011
4062011
Parkin overexpression selects against a deleterious mtDNA mutation in heteroplasmic cybrid cells
DF Suen, DP Narendra, A Tanaka, G Manfredi, RJ Youle
Proceedings of the National Academy of Sciences 107 (26), 11835-11840, 2010
3632010
Mitochondrial quality control mediated by PINK1 and Parkin: links to parkinsonism
D Narendra, JE Walker, R Youle
Cold Spring Harbor perspectives in biology 4 (11), a011338, 2012
3482012
Mitochondrial dysfunction and mitophagy in Parkinson’s disease: from mechanism to therapy
AB Malpartida, M Williamson, DP Narendra, R Wade-Martins, BJ Ryan
Trends in biochemical sciences 46 (4), 329-343, 2021
3042021
Parkin-induced mitophagy in the pathogenesis of Parkinson disease
D Narendra, A Tanaka, DF Suen, RJ Youle
Autophagy 5 (5), 706-708, 2009
2712009
PINK1 drives Parkin self-association and HECT-like E3 activity upstream of mitochondrial binding
M Lazarou, DP Narendra, SM Jin, E Tekle, S Banerjee, RJ Youle
Journal of Cell Biology 200 (2), 163-172, 2013
2492013
When patients lack capacity: the roles that patients with terminal diagnoses would choose for their physicians and loved ones in making medical decisions
MT Nolan, M Hughes, DP Narendra, JR Sood, PB Terry, AB Astrow, J Kub, ...
Journal of pain and symptom management 30 (4), 342-353, 2005
1112005
Penetrance of Parkinson's Disease in LRRK2 p.G2019S Carriers Is Modified by a Polygenic Risk Score
H Iwaki, C Blauwendraat, MB Makarious, S Bandrés‐Ciga, HL Leonard, ...
Movement Disorders 35 (5), 774-780, 2020
612020
CHCHD2 accumulates in distressed mitochondria and facilitates oligomerization of CHCHD10
X Huang, BP Wu, D Nguyen, YT Liu, M Marani, J Hench, P Bénit, ...
Human molecular genetics 27 (22), 3881-3900, 2018
592018
Loss of CHCHD2 and CHCHD10 activates OMA1 peptidase to disrupt mitochondrial cristae phenocopying patient mutations
YT Liu, X Huang, D Nguyen, MK Shammas, BP Wu, E Dombi, ...
Human Molecular Genetics 29 (9), 1547-1567, 2020
562020
Investigation of autosomal genetic sex differences in Parkinson's disease
C Blauwendraat, H Iwaki, MB Makarious, S Bandres‐Ciga, HL Leonard, ...
Annals of neurology 90 (1), 35-42, 2021
412021
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