Prati
Ian Smith
Naslov
Citirano
Citirano
Godina
Optimized sgRNA design to maximize activity and minimize off-target effects of CRISPR-Cas9
JG Doench, N Fusi, M Sullender, M Hegde, EW Vaimberg, KF Donovan, ...
Nature biotechnology 34 (2), 184-191, 2016
37022016
A next generation connectivity map: L1000 platform and the first 1,000,000 profiles
A Subramanian, R Narayan, SM Corsello, DD Peck, TE Natoli, X Lu, ...
Cell 171 (6), 1437-1452. e17, 2017
24952017
Rational design of highly active sgRNAs for CRISPR-Cas9–mediated gene inactivation
JG Doench, E Hartenian, DB Graham, Z Tothova, M Hegde, I Smith, ...
Nature biotechnology 32 (12), 1262-1267, 2014
17252014
Data-analysis strategies for image-based cell profiling
JC Caicedo, S Cooper, F Heigwer, S Warchal, P Qiu, C Molnar, ...
Nature methods 14 (9), 849-863, 2017
6092017
Sequence variants in SLC16A11 are a common risk factor for type 2 diabetes in Mexico.
AL Williams, SBR Jacobs, H Moreno-Macías, A Huerta-Chagoya, ...
Nature 506 (7486), 97-101, 2014
5512014
Evaluation of RNAi and CRISPR technologies by large-scale gene expression profiling in the Connectivity Map
I Smith, PG Greenside, T Natoli, DL Lahr, D Wadden, I Tirosh, R Narayan, ...
PLoS biology 15 (11), e2003213, 2017
2012017
In Silico Predictive Modeling of CRISPR/Cas9 guide efficiency
N Fusi, I Smith, J Doench, J Listgarten
BioRxiv, 021568, 2015
532015
Modeling cellular response in large-scale radiogenomic databases to advance precision radiotherapy
VSK Manem, M Lambie, I Smith, P Smirnov, V Kofia, M Freeman, ...
Cancer research 79 (24), 6227-6237, 2019
272019
Evaluation of statistical approaches for association testing in noisy drug screening data
P Smirnov, I Smith, Z Safikhani, W Ba-Alawi, F Khodakarami, E Lin, Y Yu, ...
BMC bioinformatics 23 (1), 188, 2022
112022
Integrative cancer pharmacogenomics to establish drug mechanism of action: drug repurposing
N El-Hachem, W Ba-Alawi, I Smith, AS Mer, B Haibe-Kains
Pharmacogenomics 18 (16), 1469-1472, 2017
52017
Meta-analysis of preclinical pharmacogenomic studies to discover robust and translatable biomarkers of drug response
P Smirnov, SK Nair, F Abbas-Aghababazadeh, N Feizi, I Smith, TJ Pugh, ...
bioRxiv, 2022.10. 22.513279, 2022
12022
Similarity bias from averaging signatures from the Connectivity Map
I Smith, B Haibe-Kains
bioRxiv, 2022
12022
On the distribution of cosine similarity with application to biology
I Smith, J Ortmann, F Abbas-Aghababazadeh, P Smirnov, B Haibe-Kains
arXiv preprint arXiv:2310.13994, 2023
2023
Detection of circular RNAs and their potential as biomarkers predictive of drug response
J Nguyen, A Mammoliti, SK Nair, E So, F Abbas-Aghababazadeh, C Eeles, ...
bioRxiv, 2023.01. 08.522775, 2023
2023
Similarity metric learning on perturbational datasets improves functional identification of perturbations
I Smith, P Smirnov, B Haibe-Kains
bioRxiv, 2023.06. 09.544397, 2023
2023
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