Prati
Mark C Julian
Mark C Julian
Scientist, Biogen
Potvrđena adresa e-pošte na biogen.com
Naslov
Citirano
Citirano
Godina
Efficient affinity maturation of antibody variable domains requires co-selection of compensatory mutations to maintain thermodynamic stability
MC Julian, L Li, S Garde, R Wilen, PM Tessier
Scientific Reports 7, 45259, 2017
1032017
Arginine mutations in antibody complementarity-determining regions display context-dependent affinity/specificity trade-offs
KE Tiller, L Li, S Kumar, MC Julian, S Garde, PM Tessier
Journal of Biological Chemistry 292 (40), 16638-16652, 2017
672017
Net charge of antibody complementarity-determining regions is a key predictor of specificity
LA Rabia, Y Zhang, SD Ludwig, MC Julian, PM Tessier
Protein Engineering, Design and Selection 31 (11), 409-418, 2018
652018
Design and optimization of anti-amyloid domain antibodies specific for β-amyloid and islet amyloid polypeptide
CC Lee, MC Julian, KE Tiller, F Meng, SE DuConge, R Akter, DP Raleigh, ...
Journal of Biological Chemistry 291 (6), 2858-2873, 2016
502016
Co-evolution of affinity and stability of grafted amyloid-motif domain antibodies
MC Julian, CC Lee, KE Tiller, LA Rabia, EK Day, AJ Schick III, PM Tessier
Protein Engineering, Design and Selection 28 (10), 339-350, 2015
402015
Nature-inspired design and evolution of anti-amyloid antibodies
MC Julian, LA Rabia, AA Desai, A Arsiwala, JE Gerson, HL Paulson, ...
Journal of Biological Chemistry 294 (21), 8438-8451, 2019
292019
Systematic engineering of optimized autonomous heavy-chain variable domains
J Nilvebrant, J Ereño-Orbea, M Gorelik, MC Julian, PM Tessier, JP Julien, ...
Journal of Molecular Biology 433 (21), 167241, 2021
52021
Directed evolution and optimization of antibodies for enhanced affinity and stability
MC Julian
Rensselaer Polytechnic Institute, 2017
2017
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