Prati
Peter W Kenny
Naslov
Citirano
Citirano
Godina
Matched molecular pairs as a guide in the optimization of pharmaceutical properties; a study of aqueous solubility, plasma protein binding and oral exposure
AG Leach, HD Jones, DA Cosgrove, PW Kenny, L Ruston, P MacFaul, ...
Journal of medicinal chemistry 49 (23), 6672-6682, 2006
2622006
Structure modification in chemical databases
PW Kenny, J Sadowski
Chemoinformatics in drug discovery, 271-285, 2005
2122005
Identification of compounds with nanomolar binding affinity for checkpoint kinase-1 using knowledge-based virtual screening
PD Lyne, PW Kenny, DA Cosgrove, C Deng, S Zabludoff, JJ Wendoloski, ...
Journal of medicinal chemistry 47 (8), 1962-1968, 2004
1582004
An integrated approach to fragment-based lead generation: philosophy, strategy and case studies from AstraZeneca's drug discovery programmes
JS Albert, N Blomberg, AL Breeze, AJH Brown, JN Burrows, PD Edwards, ...
Current topics in medicinal chemistry 7 (16), 1600-1629, 2007
1332007
Hydrogen bonding, electrostatic potential, and molecular design
PW Kenny
Journal of chemical information and modeling 49 (5), 1234-1244, 2009
1322009
Pharmacophoric pattern matching in files of three-dimensional chemical structures: Comparison of conformational-searching algorithms for flexible searching
DE Clark, G Jones, P Willett, PW Kenny, RC Glen
Journal of Chemical Information and Computer Sciences 34 (1), 197-206, 1994
1281994
Structure-based design of protein tyrosine phosphatase-1B inhibitors
E Black, J Breed, AL Breeze, K Embrey, R Garcia, TW Gero, L Godfrey, ...
Bioorganic & medicinal chemistry letters 15 (10), 2503-2507, 2005
952005
Design of compound libraries for fragment screening
N Blomberg, DA Cosgrove, PW Kenny, K Kolmodin
Journal of computer-aided molecular design 23 (8), 513-525, 2009
852009
Inflation of correlation in the pursuit of drug-likeness
PW Kenny, CA Montanari
Journal of computer-aided molecular design 27 (1), 1-13, 2013
742013
Molecular design, synthesis and trypanocidal activity of dipeptidyl nitriles as cruzain inhibitors
LAA Avelar, CD Camilo, S de Albuquerque, WB Fernandes, C Gonçalez, ...
PLOS Neglected Tropical Diseases 9 (7), e0003916, 2015
732015
Prediction of hydrogen bond basicity from computed molecular electrostatic properties: implications for comparative molecular field analysis
PW Kenny
Journal of the Chemical Society, Perkin Transactions 2, 199-202, 1994
721994
New nonpeptide angiotensin II receptor antagonists. 3. Synthesis, biological properties, and structure-activity relationships of 2-alkyl-4-(biphenylylmethoxy) pyridine derivatives
RH Bradbury, CP Allott, M Dennis, JA Girdwood, PW Kenny, JS Major, ...
Journal of medicinal chemistry 36 (9), 1245-1254, 1993
721993
Dipeptidyl nitrile inhibitors of Cathepsin L
N Asaad, PA Bethel, MD Coulson, JE Dawson, SJ Ford, S Gerhardt, ...
Bioorganic & Medicinal Chemistry Letters 19 (15), 4280-4283, 2009
562009
Ligand efficiency metrics considered harmful
PW Kenny, A Leitao, CA Montanari
Journal of computer-aided molecular design 28 (7), 699-710, 2014
532014
Toward prediction of alkane/water partition coefficients
A Toulmin, JM Wood, PW Kenny
Journal of medicinal chemistry 51 (13), 3720-3730, 2008
492008
Pharmacophoric pattern matching in files of three-dimensional chemical structures: use of bounded distance matrices for the representation and searching of conformationally …
DE Clark, P Willett, PW Kenny
Journal of molecular graphics 10 (4), 194-204, 1992
491992
Discovery of novel imidazo [1, 2-a] pyridines as inhibitors of the insulin-like growth factor-1 receptor tyrosine kinase
R Ducray, I Simpson, FH Jung, JWM Nissink, PW Kenny, M Fitzek, ...
Bioorganic & medicinal chemistry letters 21 (16), 4698-4701, 2011
472011
Development of potent, orally active 1-substituted-3, 4-dihydro-2-quinolone glycogen phosphorylase inhibitors
AM Birch, PW Kenny, NG Oikonomakos, L Otterbein, P Schofield, ...
Bioorganic & medicinal chemistry letters 17 (2), 394-399, 2007
432007
SARS-CoV-2 infects the human kidney and drives fibrosis in kidney organoids
J Jansen, KC Reimer, JS Nagai, FS Varghese, GJ Overheul, M de Beer, ...
Cell stem cell 29 (2), 217-231. e8, 2022
412022
The nature of ligand efficiency
PW Kenny
Journal of Cheminformatics 11 (1), 1-18, 2019
402019
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