| Wnt activity defines colon cancer stem cells and is regulated by the microenvironment L Vermeulen, F De Sousa E Melo, M Van Der Heijden, K Cameron, ... Nature cell biology 12 (5), 468-476, 2010 | 2033 | 2010 |
| Identification of a population of blood circulating tumor cells from breast cancer patients that initiates metastasis in a xenograft assay I Baccelli, A Schneeweiss, S Riethdorf, A Stenzinger, A Schillert, V Vogel, ... Nature biotechnology 31 (6), 539-544, 2013 | 1145 | 2013 |
| FADD/MORT1 and caspase-8 are recruited to TRAIL receptors 1 and 2 and are essential for apoptosis mediated by TRAIL receptor 2 MR Sprick, MA Weigand, E Rieser, CT Rauch, P Juo, J Blenis, ... Immunity 12 (6), 599-609, 2000 | 1011 | 2000 |
| Single-cell cloning of colon cancer stem cells reveals a multi-lineage differentiation capacity L Vermeulen, M Todaro, F de Sousa Mello, MR Sprick, K Kemper, ... Proceedings of the National Academy of Sciences 105 (36), 13427-13432, 2008 | 888 | 2008 |
| Caspase-10 is recruited to and activated at the native TRAIL and CD95 death-inducing signalling complexes in a FADD-dependent manner but can not functionally substitute caspase-8 MR Sprick, E Rieser, H Stahl, A Grosse-Wilde, MA Weigand, H Walczak The EMBO journal 21 (17), 4520-4530, 2002 | 509 | 2002 |
| Cancer stem cells–old concepts, new insights L Vermeulen, MR Sprick, K Kemper, G Stassi, JP Medema Cell Death & Differentiation 15 (6), 947-958, 2008 | 443 | 2008 |
| The AC133 epitope, but not the CD133 protein, is lost upon cancer stem cell differentiation K Kemper, MR Sprick, M de Bree, A Scopelliti, L Vermeulen, M Hoek, ... Cancer research 70 (2), 719-729, 2010 | 440 | 2010 |
| The interplay between the Bcl-2 family and death receptor-mediated apoptosis MR Sprick, H Walczak Biochimica et Biophysica Acta (BBA)-Molecular Cell Research 1644 (2-3), 125-132, 2004 | 332 | 2004 |
| Enhanced caspase-8 recruitment to and activation at the DISC is critical for sensitisation of human hepatocellular carcinoma cells to TRAIL-induced apoptosis by … TM Ganten, TL Haas, J Sykora, H Stahl, MR Sprick, SC Fas, A Krueger, ... Cell Death & Differentiation 11 (1), S86-S96, 2004 | 258 | 2004 |
| CYP3A5 mediates basal and acquired therapy resistance in different subtypes of pancreatic ductal adenocarcinoma EM Noll, C Eisen, A Stenzinger, E Espinet, A Muckenhuber, C Klein, ... Nature medicine 22 (3), 278-287, 2016 | 197 | 2016 |
| Screening drug effects in patient‐derived cancer cells links organoid responses to genome alterations J Jabs, FM Zickgraf, J Park, S Wagner, X Jiang, K Jechow, K Kleinheinz, ... Molecular systems biology 13 (11), 955, 2017 | 188 | 2017 |
| Oncogenic K-Ras turns death receptors into metastasis-promoting receptors in human and mouse colorectal cancer cells FJH Hoogwater, MW Nijkamp, N Smakman, EJA Steller, BL Emmink, ... Gastroenterology 138 (7), 2357-2367, 2010 | 166 | 2010 |
| Survival of pancreatic cancer cells lacking KRAS function MD Muzumdar, PY Chen, KJ Dorans, KM Chung, A Bhutkar, E Hong, ... Nature communications 8 (1), 1090, 2017 | 154 | 2017 |
| Suppression of cFLIP is sufficient to sensitize human melanoma cells to TRAIL-and CD95L-mediated apoptosis P Geserick, C Drewniok, M Hupe, TL Haas, P Diessenbacher, MR Sprick, ... Oncogene 27 (22), 3211-3220, 2008 | 152 | 2008 |
| Proteasome Inhibition Results in TRAIL Sensitization of Primary Keratinocytes by Removing the Resistance-Mediating Block of Effector Caspase Maturation M Leverkus, MR Sprick, T Wachter, T Mengling, B Baumann, E Serfling, ... Molecular and Cellular Biology 23 (3), 777-790, 2003 | 152 | 2003 |
| TNF-related apoptosis-inducing ligand mediates tumoricidal activity of human monocytes stimulated by Newcastle disease virus B Washburn, MA Weigand, A Grosse-Wilde, M Janke, H Stahl, E Rieser, ... The Journal of Immunology 170 (4), 1814-1821, 2003 | 145 | 2003 |
| Saa3 is a key mediator of the protumorigenic properties of cancer-associated fibroblasts in pancreatic tumors M Djurec, O Graña, A Lee, K Troulé, E Espinet, L Cabras, C Navas, ... Proceedings of the National Academy of Sciences 115 (6), E1147-E1156, 2018 | 144 | 2018 |
| TRAIL/bortezomib cotreatment is potentially hepatotoxic but induces cancer‐specific apoptosis within a therapeutic window R Koschny, TM Ganten, J Sykora, TL Haas, MR Sprick, A Kolb, ... Hepatology 45 (3), 649-658, 2007 | 141 | 2007 |
| Bortezomib Sensitizes Primary Human Astrocytoma Cells of WHO Grades I to IV for Tumor Necrosis Factor–Related Apoptosis-Inducing Ligand–Induced Apoptosis R Koschny, H Holland, J Sykora, TL Haas, MR Sprick, TM Ganten, ... Clinical cancer research 13 (11), 3403-3412, 2007 | 133 | 2007 |
| A synergistic interaction between Chk1-and MK2 inhibitors in KRAS-mutant cancer F Dietlein, B Kalb, M Jokic, EM Noll, A Strong, L Tharun, L Ozretić, ... Cell 162 (1), 146-159, 2015 | 130 | 2015 |
Andreas TrumppHI-STEM & DKFZ, Heidelberg, GermanyVerified email at hi-stem.de
