| Organoid cultures derived from patients with advanced prostate cancer D Gao, I Vela, A Sboner, PJ Iaquinta, WR Karthaus, A Gopalan, ... Cell 159 (1), 176-187, 2014 | 1445 | 2014 |
| Wnt signaling through inhibition of β-catenin degradation in an intact Axin1 complex VSW Li, SS Ng, PJ Boersema, TY Low, WR Karthaus, JP Gerlach, ... Cell 149 (6), 1245-1256, 2012 | 1001 | 2012 |
| SOX2 promotes lineage plasticity and antiandrogen resistance in TP53-and RB1-deficient prostate cancer P Mu, Z Zhang, M Benelli, WR Karthaus, E Hoover, CC Chen, ... Science 355 (6320), 84-88, 2017 | 880 | 2017 |
| Identification of multipotent luminal progenitor cells in human prostate organoid cultures WR Karthaus, PJ Iaquinta, J Drost, A Gracanin, R Van Boxtel, J Wongvipat, ... Cell 159 (1), 163-175, 2014 | 707 | 2014 |
| Organoid culture systems for prostate epithelial and cancer tissue J Drost, WR Karthaus, D Gao, E Driehuis, CL Sawyers, Y Chen, H Clevers Nature protocols 11 (2), 347-358, 2016 | 563 | 2016 |
| Efficient intracellular delivery of native proteins DS D’Astolfo, RJ Pagliero, A Pras, WR Karthaus, H Clevers, V Prasad, ... Cell 161 (3), 674-690, 2015 | 378 | 2015 |
| Genome sequencing of normal cells reveals developmental lineages and mutational processes S Behjati, M Huch, R Van Boxtel, W Karthaus, DC Wedge, AU Tamuri, ... Nature 513 (7518), 422-425, 2014 | 370 | 2014 |
| A rectal cancer organoid platform to study individual responses to chemoradiation K Ganesh, C Wu, KP O’Rourke, BC Szeglin, Y Zheng, CEG Sauvé, ... Nature medicine 25 (10), 1607-1614, 2019 | 363 | 2019 |
| Controlled gene expression in primary Lgr5 organoid cultures BK Koo, DE Stange, T Sato, W Karthaus, HF Farin, M Huch, JH Van Es, ... Nature methods 9 (1), 81-83, 2012 | 360 | 2012 |
| Reg4+ deep crypt secretory cells function as epithelial niche for Lgr5+ stem cells in colon N Sasaki, N Sachs, K Wiebrands, SIJ Ellenbroek, A Fumagalli, ... Proceedings of the National Academy of Sciences 113 (37), E5399-E5407, 2016 | 329 | 2016 |
| The role of CD133 in normal human prostate stem cells and malignant cancer-initiating cells DJ Vander Griend, WL Karthaus, S Dalrymple, A Meeker, AM DeMarzo, ... Cancer research 68 (23), 9703-9711, 2008 | 305 | 2008 |
| Patient derived organoids to model rare prostate cancer phenotypes L Puca, R Bareja, D Prandi, R Shaw, M Benelli, WR Karthaus, J Hess, ... Nature communications 9 (1), 2404, 2018 | 293 | 2018 |
| Paneth cell extrusion and release of antimicrobial products is directly controlled by immune cell–derived IFN-γ HF Farin, WR Karthaus, P Kujala, M Rakhshandehroo, G Schwank, ... Journal of Experimental Medicine 211 (7), 1393-1405, 2014 | 282 | 2014 |
| FOXA1 mutations alter pioneering activity, differentiation and prostate cancer phenotypes EJ Adams, WR Karthaus, E Hoover, D Liu, A Gruet, Z Zhang, H Cho, ... Nature 571 (7765), 408-412, 2019 | 190 | 2019 |
| Regenerative potential of prostate luminal cells revealed by single-cell analysis WR Karthaus, M Hofree, D Choi, EL Linton, M Turkekul, A Bejnood, ... Science 368 (6490), 497-505, 2020 | 189 | 2020 |
| Tumor microenvironment-derived NRG1 promotes antiandrogen resistance in prostate cancer Z Zhang, WR Karthaus, YS Lee, VR Gao, C Wu, JW Russo, M Liu, ... Cancer Cell 38 (2), 279-296. e9, 2020 | 166 | 2020 |
| Regulation of the glucocorticoid receptor via a BET-dependent enhancer drives antiandrogen resistance in prostate cancer N Shah, P Wang, J Wongvipat, WR Karthaus, W Abida, J Armenia, ... Elife 6, e27861, 2017 | 163 | 2017 |
| Lineage plasticity in prostate cancer depends on JAK/STAT inflammatory signaling JM Chan, S Zaidi, JR Love, JL Zhao, M Setty, KM Wadosky, A Gopalan, ... Science 377 (6611), 1180-1191, 2022 | 107 | 2022 |
| ERF mutations reveal a balance of ETS factors controlling prostate oncogenesis R Bose, WR Karthaus, J Armenia, W Abida, PJ Iaquinta, Z Zhang, ... Nature 546 (7660), 671-675, 2017 | 80 | 2017 |
| FOXA1 mutations reveal distinct chromatin profiles and influence therapeutic response in breast cancer A Arruabarrena-Aristorena, JLV Maag, S Kittane, Y Cai, WR Karthaus, ... Cancer cell 38 (4), 534-550. e9, 2020 | 74 | 2020 |
Charles SawyersMemorial Sloan Kettering Cancer CenterVerified email at mskcc.org
