| Aptamers as targeted therapeutics: current potential and challenges J Zhou, J Rossi Nature reviews Drug discovery 16 (3), 181-202, 2017 | 1728 | 2017 |
| Expression of small interfering RNAs targeted against HIV-1 rev transcripts in human cells NS Lee, T Dohjima, G Bauer, H Li, MJ Li, A Ehsani, P Salvaterra, J Rossi Nature biotechnology 20 (5), 500-505, 2002 | 1619 | 2002 |
| The promises and pitfalls of RNA-interference-based therapeutics D Castanotto, JJ Rossi Nature 457 (7228), 426-433, 2009 | 1556 | 2009 |
| Unlocking the potential of the human genome with RNA interference GJ Hannon, JJ Rossi Nature 431 (7006), 371-378, 2004 | 1544 | 2004 |
| Strategies for silencing human disease using RNA interference DH Kim, JJ Rossi Nature Reviews Genetics 8 (3), 173-184, 2007 | 1393 | 2007 |
| Synthetic dsRNA Dicer substrates enhance RNAi potency and efficacy DH Kim, MA Behlke, SD Rose, MS Chang, S Choi, JJ Rossi Nature biotechnology 23 (2), 222-226, 2005 | 1256 | 2005 |
| RNAi therapeutics: principles, prospects and challenges L Aagaard, JJ Rossi Advanced drug delivery reviews 59 (2-3), 75-86, 2007 | 1165 | 2007 |
| The current state and future directions of RNAi-based therapeutics RL Setten, JJ Rossi, S Han Nature reviews Drug discovery 18 (6), 421-446, 2019 | 1112 | 2019 |
| RNA-based therapeutics: current progress and future prospects JC Burnett, JJ Rossi Chemistry & biology 19 (1), 60-71, 2012 | 1108 | 2012 |
| Ribozymes as potential anti-HIV-1 therapeutic agents N Sarver, EM Cantin, PS Chang, JA Zaia, PA Ladne, DA Stephens, ... Science 247 (4947), 1222-1225, 1990 | 990 | 1990 |
| MicroRNA-directed transcriptional gene silencing in mammalian cells DH Kim, P Sætrom, O Snøve Jr, JJ Rossi Proceedings of the National Academy of Sciences 105 (42), 16230-16235, 2008 | 891 | 2008 |
| MicroRNA-192 in diabetic kidney glomeruli and its function in TGF-β-induced collagen expression via inhibition of E-box repressors M Kato, J Zhang, M Wang, L Lanting, H Yuan, JJ Rossi, R Natarajan Proceedings of the National Academy of Sciences 104 (9), 3432-3437, 2007 | 887 | 2007 |
| TGF-β activates Akt kinase through a microRNA-dependent amplifying circuit targeting PTEN M Kato, S Putta, M Wang, H Yuan, L Lanting, I Nair, A Gunn, Y Nakagawa, ... Nature cell biology 11 (7), 881-889, 2009 | 689 | 2009 |
| Approaches for the sequence-specific knockdown of mRNA LJ Scherer, JJ Rossi Nature biotechnology 21 (12), 1457-1465, 2003 | 679 | 2003 |
| Current progress of siRNA/shRNA therapeutics in clinical trials JC Burnett, JJ Rossi, K Tiemann Biotechnology journal 6 (9), 1130-1146, 2011 | 623 | 2011 |
| Interferon induction by siRNAs and ssRNAs synthesized by phage polymerase DH Kim, M Longo, Y Han, P Lundberg, E Cantin, JJ Rossi Nature biotechnology 22 (3), 321-325, 2004 | 555 | 2004 |
| Argonaute-1 directs siRNA-mediated transcriptional gene silencing in human cells DH Kim, LM Villeneuve, KV Morris, JJ Rossi Nature structural & molecular biology 13 (9), 793-797, 2006 | 549 | 2006 |
| Functional polarity is introduced by Dicer processing of short substrate RNAs SD Rose, DH Kim, M Amarzguioui, JD Heidel, MA Collingwood, ME Davis, ... Nucleic acids research 33 (13), 4140-4156, 2005 | 527 | 2005 |
| SNPs in human miRNA genes affect biogenesis and function G Sun, J Yan, K Noltner, J Feng, H Li, DA Sarkis, SS Sommer, JJ Rossi Rna 15 (9), 1640-1651, 2009 | 518 | 2009 |
| RNA-based gene therapy for HIV with lentiviral vector–modified CD34+ cells in patients undergoing transplantation for AIDS-related lymphoma DL DiGiusto, A Krishnan, L Li, H Li, S Li, A Rao, S Mi, P Yam, S Stinson, ... Science translational medicine 2 (36), 36ra43-36ra43, 2010 | 510 | 2010 |
