| The diagnosis of mild cognitive impairment due to Alzheimer’s disease: recommendations from the National Institute on Aging-Alzheimer’s Association workgroups on diagnostic … MS Albert, ST DeKosky, D Dickson, B Dubois, HH Feldman, NC Fox, ... Focus 11 (1), 96-106, 2013 | 11043 | 2013 |
| NIA-AA research framework: toward a biological definition of Alzheimer's disease CR Jack Jr, DA Bennett, K Blennow, MC Carrillo, B Dunn, SB Haeberlein, ... Alzheimer's & Dementia 14 (4), 535-562, 2018 | 7157 | 2018 |
| Inflammation and Alzheimer’s disease H Akiyama, S Barger, S Barnum, B Bradt, J Bauer, GM Cole, NR Cooper, ... Neurobiology of aging 21 (3), 383-421, 2000 | 5618 | 2000 |
| Clinical and biomarker changes in dominantly inherited Alzheimer's disease RJ Bateman, C Xiong, TLS Benzinger, AM Fagan, A Goate, NC Fox, ... New England Journal of Medicine 367 (9), 795-804, 2012 | 3974 | 2012 |
| National Institute of Neurological Disorders and Stroke–Canadian stroke network vascular cognitive impairment harmonization standards V Hachinski, C Iadecola, RC Petersen, MM Breteler, DL Nyenhuis, ... Stroke 37 (9), 2220-2241, 2006 | 2225 | 2006 |
| Alzheimer disease: an update on pathobiology and treatment strategies JM Long, DM Holtzman Cell 179 (2), 312-339, 2019 | 2038 | 2019 |
| The TREM2-APOE pathway drives the transcriptional phenotype of dysfunctional microglia in neurodegenerative diseases S Krasemann, C Madore, R Cialic, C Baufeld, N Calcagno, R El Fatimy, ... Immunity 47 (3), 566-581. e9, 2017 | 1992 | 2017 |
| The role of apolipoprotein E in Alzheimer's disease J Kim, JM Basak, DM Holtzman Neuron 63 (3), 287-303, 2009 | 1895 | 2009 |
| Preclinical Alzheimer's disease: definition, natural history, and diagnostic criteria B Dubois, H Hampel, HH Feldman, P Scheltens, P Aisen, S Andrieu, ... Alzheimer's & Dementia 12 (3), 292-323, 2016 | 1751 | 2016 |
| Peripheral anti-Aβ antibody alters CNS and plasma Aβ clearance and decreases brain Aβ burden in a mouse model of Alzheimer's disease RB DeMattos, KR Bales, DJ Cummins, JC Dodart, SM Paul, DM Holtzman Proceedings of the National Academy of Sciences 98 (15), 8850-8855, 2001 | 1742 | 2001 |
| Clearance of Alzheimer’s amyloid-β1-40 peptide from brain by LDL receptor–related protein-1 at the blood-brain barrier M Shibata, S Yamada, SR Kumar, M Calero, J Bading, B Frangione, ... The Journal of clinical investigation 106 (12), 1489-1499, 2000 | 1721 | 2000 |
| Alzheimer’s disease: the challenge of the second century DM Holtzman, JC Morris, AM Goate Science translational medicine 3 (77), 77sr1-77sr1, 2011 | 1683 | 2011 |
| Amyloid-β dynamics are regulated by orexin and the sleep-wake cycle JE Kang, MM Lim, RJ Bateman, JJ Lee, LP Smyth, JR Cirrito, N Fujiki, ... Science 326 (5955), 1005-1007, 2009 | 1605 | 2009 |
| TREM2 lipid sensing sustains the microglial response in an Alzheimer’s disease model Y Wang, M Cella, K Mallinson, JD Ulrich, KL Young, ML Robinette, ... Cell 160 (6), 1061-1071, 2015 | 1514 | 2015 |
| Inverse relation between in vivo amyloid imaging load and cerebrospinal fluid Aβ42 in humans AM Fagan, MA Mintun, RH Mach, SY Lee, CS Dence, AR Shah, ... Annals of neurology 59 (3), 512-519, 2006 | 1507 | 2006 |
| Synaptic activity regulates interstitial fluid amyloid-β levels in vivo JR Cirrito, KA Yamada, MB Finn, RS Sloviter, KR Bales, PC May, ... Neuron 48 (6), 913-922, 2005 | 1409 | 2005 |
| Human apoE isoforms differentially regulate brain amyloid-β peptide clearance JM Castellano, J Kim, FR Stewart, H Jiang, RB DeMattos, BW Patterson, ... Science translational medicine 3 (89), 89ra57-89ra57, 2011 | 1385 | 2011 |
| Apolipoprotein E controls cerebrovascular integrity via cyclophilin A RD Bell, EA Winkler, I Singh, AP Sagare, R Deane, Z Wu, DM Holtzman, ... Nature 485 (7399), 512-516, 2012 | 1267 | 2012 |
| Immunization reverses memory deficits without reducing brain Aβ burden in Alzheimer's disease model JC Dodart, KR Bales, KS Gannon, SJ Greene, RB DeMattos, C Mathis, ... Nature neuroscience 5 (5), 452-457, 2002 | 1236 | 2002 |
| Rapid appearance and local toxicity of amyloid-β plaques in a mouse model of Alzheimer’s disease M Meyer-Luehmann, TL Spires-Jones, C Prada, M Garcia-Alloza, ... Nature 451 (7179), 720-724, 2008 | 1187 | 2008 |
