Prati
Ping-Shan Lai
Ping-Shan Lai
Medicinal chemist, Dalriada Drug Discovery Inc.
Potvrđena adresa e-pošte na utoronto.ca
Naslov
Citirano
Citirano
Godina
CD133+ brain tumor-initiating cells are dependent on STAT3 signaling to drive medulloblastoma recurrence
N Garg, D Bakhshinyan, C Venugopal, S Mahendram, DA Rosa, ...
Oncogene 36 (5), 606-617, 2017
672017
STAT3 pathway regulates lung-derived brain metastasis initiating cell capacity through miR-21 activation
M Singh, N Garg, C Venugopal, R Hallett, T Tokar, N McFarlane, ...
Oncotarget 6 (29), 27461, 2015
652015
Carbon–carbon bond-forming reactions of α-carbonyl carbocations: exploration of a reversed-polarity equivalent of enolate chemistry
PS Lai, JA Dubland, MG Sarwar, MG Chudzinski, MS Taylor
Tetrahedron 67 (39), 7586-7592, 2011
652011
A STAT inhibitor patent review: progress since 2011
PS Lai, DA Rosa, A Magdy Ali, RF Gómez-Biagi, DP Ball, AE Shouksmith, ...
Expert opinion on therapeutic patents 25 (12), 1397-1421, 2015
612015
Applying small molecule signal transducer and activator of transcription-3 (STAT3) protein inhibitors as pancreatic cancer therapeutics
CC Arpin, S Mac, Y Jiang, H Cheng, M Grimard, BDG Page, MM Kamocka, ...
Molecular cancer therapeutics 15 (5), 794-805, 2016
392016
Disarming an Electrophilic Warhead: Retaining Potency in Tyrosine Kinase Inhibitor (TKI)‐Resistant CML Lines While Circumventing Pharmacokinetic Liabilities
AM Ali, RF Gómez‐Biagi, DA Rosa, PS Lai, WL Heaton, JS Park, ...
ChemMedChem 11 (8), 850-861, 2016
372016
Preparation of substituted oxazoles by Ritter reactions of α-oxo tosylates
PS Lai, MS Taylor
Synthesis 2010 (09), 1449-1452, 2010
282010
Directed ortho metalation-boronation Suzuki-Miyaura cross coupling leading to synthesis of azafluorenol core liquid crystals
PS Lai
22007
A STAT inhibitor patent review: progress since 2011 (vol 25, pg 1397, 2015)
PS Lai, DA Rosa, MA Ali, RF Gomez-Biagi, DP Ball, AE Shouksmith, ...
EXPERT OPINION ON THERAPEUTIC PATENTS 25 (12), 1495-1495, 2015
2015
Developing Inhibitors of STAT3: Targeting Downstream of the Kinases for Treating Disease
AM Lewis, DP Ball, R Rana, JS Park, D Rosa, PS Lai, RF Gómez-Biagi, ...
Kinomics: Approaches and Applications, 2015
2015
a-keto Carbocations-Umpolung of enolate reactivity for the construction of CC and CN bonds
PS Lai, J Dubland, MG Sarwar, MS Taylor
ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY 242, 2011
2011
Department of Chemistry, University of Toronto, 80 St. George St., Toronto, ON M5S 3H6 Canada
PS Lai, JA Dubland, MG Sarwar, MG Chudzinski, MS Taylor
2011
Applications of α-Keto Carbocations in Carbon-Carbon and Carbon-Nitrogen Bond Formation
PS Lai
2011
In-Situ Directed Ortho Metalation (DoM)-Boronation Suzuki-Miyaura Cross Coupling of Pyridine Derivatives
M Alessi, A Larkin, L Green, K Ogilvie, S Lai, S Lopez, V Snieckus
Journal of Organic Chemistry 72, 3199, 2007
2007
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