Prati
Gregory Arthur Newby
Gregory Arthur Newby
Assistant Professor, Johns Hopkins University Department of Genetic Medicine
Potvrđena adresa e-pošte na jhmi.edu
Naslov
Citirano
Citirano
Godina
Search-and-replace genome editing without double-strand breaks or donor DNA
AV Anzalone, PB Randolph, JR Davis, AA Sousa, LW Koblan, JM Levy, ...
Nature 576 (7785), 149-157, 2019
33812019
Improving cytidine and adenine base editors by expression optimization and ancestral reconstruction
LW Koblan, JL Doman, C Wilson, JM Levy, T Tay, GA Newby, JP Maianti, ...
Nature biotechnology 36 (9), 843-846, 2018
7622018
Phage-assisted evolution of an adenine base editor with improved Cas domain compatibility and activity
MF Richter, KT Zhao, E Eton, A Lapinaite, GA Newby, BW Thuronyi, ...
Nature biotechnology 38 (7), 883-891, 2020
6112020
Enhanced prime editing systems by manipulating cellular determinants of editing outcomes
PJ Chen, JA Hussmann, J Yan, F Knipping, P Ravisankar, PF Chen, ...
Cell 184 (22), 5635-5652. e29, 2021
3962021
Engineered pegRNAs improve prime editing efficiency
JW Nelson, PB Randolph, SP Shen, KA Everette, PJ Chen, AV Anzalone, ...
Nature biotechnology 40 (3), 402-410, 2022
3552022
Continuous evolution of base editors with expanded target compatibility and improved activity
BW Thuronyi, LW Koblan, JM Levy, WH Yeh, C Zheng, GA Newby, ...
Nature biotechnology 37 (9), 1070-1079, 2019
3352019
In vivo base editing rescues Hutchinson–Gilford progeria syndrome in mice
LW Koblan, MR Erdos, C Wilson, WA Cabral, JM Levy, ZM Xiong, ...
Nature 589 (7843), 608-614, 2021
3312021
Evaluation and minimization of Cas9-independent off-target DNA editing by cytosine base editors
JL Doman, A Raguram, GA Newby, DR Liu
Nature biotechnology 38 (5), 620-628, 2020
3292020
Continuous evolution of SpCas9 variants compatible with non-G PAMs
SM Miller, T Wang, PB Randolph, M Arbab, MW Shen, TP Huang, ...
Nature biotechnology 38 (4), 471-481, 2020
2852020
Engineered virus-like particles for efficient in vivo delivery of therapeutic proteins
S Banskota, A Raguram, S Suh, SW Du, JR Davis, EH Choi, X Wang, ...
Cell 185 (2), 250-265. e16, 2022
2772022
Base editing of haematopoietic stem cells rescues sickle cell disease in mice
GA Newby, JS Yen, KJ Woodard, T Mayuranathan, CR Lazzarotto, Y Li, ...
Nature 595 (7866), 295-302, 2021
2292021
Lipidomic analysis of α-synuclein neurotoxicity identifies stearoyl CoA desaturase as a target for Parkinson treatment
S Fanning, A Haque, T Imberdis, V Baru, MI Barrasa, S Nuber, D Termine, ...
Molecular cell 73 (5), 1001-1014. e8, 2019
2202019
Cross-kingdom chemical communication drives a heritable, mutually beneficial prion-based transformation of metabolism
DF Jarosz, JCS Brown, GA Walker, MS Datta, WL Ung, AK Lancaster, ...
Cell 158 (5), 1083-1093, 2014
1782014
Blessings in disguise: biological benefits of prion-like mechanisms
GA Newby, S Lindquist
Trends in cell biology 23 (6), 251-259, 2013
1592013
Efficient C• G-to-G• C base editors developed using CRISPRi screens, target-library analysis, and machine learning
LW Koblan, M Arbab, MW Shen, JA Hussmann, AV Anzalone, JL Doman, ...
Nature biotechnology 39 (11), 1414-1425, 2021
1462021
In vivo base editing restores sensory transduction and transiently improves auditory function in a mouse model of recessive deafness
WH Yeh, O Shubina-Oleinik, JM Levy, B Pan, GA Newby, M Wornow, ...
Science translational medicine 12 (546), eaay9101, 2020
1442020
Precision genome editing using cytosine and adenine base editors in mammalian cells
TP Huang, GA Newby, DR Liu
Nature protocols 16 (2), 1089-1128, 2021
1182021
In vivo somatic cell base editing and prime editing
GA Newby, DR Liu
Molecular Therapy 29 (11), 3107-3124, 2021
1052021
Restoration of visual function in adult mice with an inherited retinal disease via adenine base editing
S Suh, EH Choi, H Leinonen, AT Foik, GA Newby, WH Yeh, Z Dong, ...
Nature biomedical engineering 5 (2), 169-178, 2021
1012021
Chemical modifications of adenine base editor mRNA and guide RNA expand its application scope
T Jiang, JM Henderson, K Coote, Y Cheng, HC Valley, XO Zhang, ...
Nature communications 11 (1), 1979, 2020
942020
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