Antony Rosen
Antony Rosen
Mary Betty Stevens Professor of Medicine, Johns Hopkins
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Autoantigens targeted in systemic lupus erythematosus are clustered in two populations of surface structures on apoptotic keratinocytes.
LA Casciola-Rosen, G Anhalt, A Rosen
Journal of Experimental Medicine 179 (4), 1317-1330, 1994
Apopain/CPP32 cleaves proteins that are essential for cellular repair: a fundamental principle of apoptotic death.
L Casciola-Rosen, DW Nicholson, T Chong, KR Rowan, NA Thornberry, ...
The Journal of experimental medicine 183 (5), 1957-1964, 1996
Cleavage by granzyme B is strongly predictive of autoantigen status: implications for initiation of autoimmunity
L Casciola-Rosen, F Andrade, D Ulanet, WB Wong, A Rosen
The Journal of experimental medicine 190 (6), 815-826, 1999
Autoantibodies against 3‐hydroxy‐3‐methylglutaryl‐coenzyme A reductase in patients with statin‐associated autoimmune myopathy
AL Mammen, T Chung, L Christopher‐Stine, P Rosen, A Rosen, ...
Arthritis & Rheumatism 63 (3), 713-721, 2011
Surface blebs on apoptotic cells are sites of enhanced procoagulant activity: implications for coagulation events and antigenic spread in systemic lupus erythematosus
L Casciola-Rosen, A Rosen, M Petri, M Schlissel
Proceedings of the National Academy of Sciences 93 (4), 1624-1629, 1996
Rheumatoid arthritis associated autoantibodies in patients with synovitis of recent onset
R Goldbach-Mansky, J Lee, A McCoy, J Hoxworth, C Yarboro, JS Smolen, ...
Arthritis Research & Therapy 2 (3), 236, 2000
Specific cleavage of the 70-kDa protein component of the U1 small nuclear ribonucleoprotein is a characteristic biochemical feature of apoptotic cell death.
LA Casciola-Rosen, DK Miller, GJ Anhalt, A Rosen
Journal of Biological Chemistry 269 (49), 30757-30760, 1994
DNA-dependent protein kinase is one of a subset of autoantigens specifically cleaved early during apoptosis.
LA Casciola-Rosen, GJ Anhalt, A Rosen
The Journal of experimental medicine 182 (6), 1625-1634, 1995
The caspase-3 precursor has a cytosolic and mitochondrial distribution: implications for apoptotic signaling
M Mancini, DW Nicholson, S Roy, NA Thornberry, EP Peterson, ...
The Journal of cell biology 140 (6), 1485-1495, 1998
Caspase-2 is localized at the Golgi complex and cleaves golgin-160 during apoptosis
M Mancini, CE Machamer, S Roy, DW Nicholson, NA Thornberry, ...
The Journal of cell biology 149 (3), 603-612, 2000
Autoantigens as substrates for apoptotic proteases: implications for the pathogenesis of systemic autoimmune disease
A Rosen, L Casciola-Rosen
Cell Death & Differentiation 6 (1), 6-12, 1999
Regulation by phosphorylation of reversible association of a myristoylated protein kinase C substrate with the plasma membrane
M Thelen, A Rosen, AC Nairn, A Aderem
Nature 351 (6324), 320-322, 1991
Granzyme B directly and efficiently cleaves several downstream caspase substrates: implications for CTL-induced apoptosis
F Andrade, S Roy, D Nicholson, N Thornberry, A Rosen, ...
Immunity 8 (4), 451-460, 1998
The mucocutaneous and systemic phenotype of dermatomyositis patients with antibodies to MDA5 (CADM-140): a retrospective study
D Fiorentino, L Chung, J Zwerner, A Rosen, L Casciola-Rosen
Journal of the American Academy of Dermatology 65 (1), 25-34, 2011
Enhanced autoantigen expression in regenerating muscle cells in idiopathic inflammatory myopathy
L Casciola-Rosen, K Nagaraju, P Plotz, K Wang, S Levine, E Gabrielson, ...
Journal of Experimental Medicine 201 (4), 591-601, 2005
Hsp60 accelerates the maturation of pro‐caspase‐3 by upstream activator proteases during apoptosis
S Xanthoudakis, S Roy, D Rasper, T Hennessey, Y Aubin, R Cassady, ...
The EMBO journal 18 (8), 2049-2056, 1999
Histidyl–tRNA synthetase and asparaginyl–tRNA synthetase, autoantigens in myositis, activate chemokine receptors on T lymphocytes and immature dendritic cells
OMZ Howard, HF Dong, D Yang, N Raben, K Nagaraju, A Rosen, ...
The Journal of experimental medicine 196 (6), 781-791, 2002
Association of the autoimmune disease scleroderma with an immunologic response to cancer
CG Joseph, E Darrah, AA Shah, AD Skora, LA Casciola-Rosen, ...
Science 343 (6167), 152-157, 2014
Activation of the endoplasmic reticulum stress response in autoimmune myositis: potential role in muscle fiber damage and dysfunction
K Nagaraju, L Casciola‐Rosen, I Lundberg, R Rawat, S Cutting, ...
Arthritis & Rheumatism 52 (6), 1824-1835, 2005
Novel packages of viral and self-antigens are generated during apoptosis.
A Rosen, L Casciola-Rosen, J Ahearn
The Journal of experimental medicine 181 (4), 1557-1561, 1995
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