| Thymocyte apoptosis induced by p53-dependent and independent pathways AR Clarke, CA Purdie, DJ Harrison, RG Morris, CC Bird, ML Hooper, ... Nature 362 (6423), 849-852, 1993 | 3069 | 1993 |
| Crypt stem cells as the cells-of-origin of intestinal cancer N Barker, RA Ridgway, JH Van Es, M Van De Wetering, H Begthel, ... Nature 457 (7229), 608-611, 2009 | 2447 | 2009 |
| Requirement for a functional Rb-1 gene in murine development AR Clarke, ER Maandag, M van Roon, NMT van der Lugt, M van der Valk, ... Nature 359 (6393), 328-330, 1992 | 1329 | 1992 |
| Mutations in T-cell antigen receptor genes α and β block thymocyte development at different stages P Mombaerts, AR Clarke, MA Rudnicki, J Iacomini, S Itohara, JJ Lafaille, ... Nature 360 (6401), 225-231, 1992 | 1300 | 1992 |
| Loss of Apc in vivo immediately perturbs Wnt signaling, differentiation, and migration OJ Sansom, KR Reed, AJ Hayes, H Ireland, H Brinkmann, IP Newton, ... Genes & development 18 (12), 1385-1390, 2004 | 955 | 2004 |
| 129/Ola mice carrying a null mutation in PrP that abolishes mRNA production are developmentally normal JC Manson, AR Clarke, ML Hooper, L Aitchison, I McConnell, J Hope Molecular neurobiology 8, 121-127, 1994 | 759 | 1994 |
| Myc deletion rescues Apc deficiency in the small intestine OJ Sansom, VS Meniel, V Muncan, TJ Phesse, JA Wilkins, KR Reed, ... Nature 446 (7136), 676-679, 2007 | 675 | 2007 |
| Germ line transmission and expression of a corrected HPRT gene produced by gene targeting in embryonic stem cells S Thompson, AR Clarke, AM Pow, ML Hooper, DW Melton Cell 56 (2), 313-321, 1989 | 653 | 1989 |
| Suppression of epithelial apoptosis and delayed mammary gland involution in mice with a conditional knockout of Stat3 RS Chapman, PC Lourenco, E Tonner, DJ Flint, S Selbert, K Takeda, ... Genes & development 13 (19), 2604-2616, 1999 | 639 | 1999 |
| High-frequency developmental abnormalities in p53-deficient mice JF Armstrong, MH Kaufman, DJ Harrison, AR Clarke Current Biology 5 (8), 931-936, 1995 | 592 | 1995 |
| T cell receptor δ gene mutant mice: independent generation of αβ T cells and programmed rearrangements of γδ TCR genes S Itohara, P Mombaerts, J Lafaille, J Iacomini, A Nelson, AR Clarke, ... Cell 72 (3), 337-348, 1993 | 590 | 1993 |
| Outcomes of the Bowel Cancer Screening Programme (BCSP) in England after the first 1 million tests RFA Logan, J Patnick, C Nickerson, L Coleman, MD Rutter, ... Gut 61 (10), 1439-1446, 2012 | 588 | 2012 |
| Hepatic progenitor cells of biliary origin with liver repopulation capacity WY Lu, TG Bird, L Boulter, A Tsuchiya, AM Cole, T Hay, RV Guest, ... Nature cell biology 17 (8), 971-983, 2015 | 458 | 2015 |
| Tumour incidence, spectrum and ploidy in mice with a large deletion in the p53 gene. CA Purdie, DJ Harrison, A Peter, L Dobbie, S White, SE Howie, DM Salter, ... Oncogene 9 (2), 603-609, 1994 | 422 | 1994 |
| Enhanced CpG mutability and tumorigenesis in MBD4-deficient mice CB Millar, J Guy, OJ Sansom, J Selfridge, E MacDougall, B Hendrich, ... Science 297 (5580), 403-405, 2002 | 403 | 2002 |
| Inducible Cre-mediated control of gene expression in the murine gastrointestinal tract: effect of loss of β-catenin H Ireland, R Kemp, C Houghton, L Howard, AR Clarke, OJ Sansom, ... Gastroenterology 126 (5), 1236-1246, 2004 | 401 | 2004 |
| p53 dependence of early apoptotic and proliferative responses within the mouse intestinal epithelium following gamma-irradiation. AR Clarke, S Gledhill, ML Hooper, CC Bird, AH Wyllie Oncogene 9 (6), 1767-1773, 1994 | 394 | 1994 |
| Cystic fibrosis in the mouse by targeted insertional mutagenesis JR Dorin, P Dickinson, EWFW Alton, SN Smith, DM Geddes, ... Nature 359 (6392), 211-215, 1992 | 385 | 1992 |
| WT1 is a key regulator of podocyte function: reduced expression levels cause crescentic glomerulonephritis and mesangial sclerosis JK Guo, AL Menke, MC Gubler, AR Clarke, D Harrison, A Hammes, ... Human molecular genetics 11 (6), 651-659, 2002 | 346 | 2002 |
| PrP gene dosage determines the timing but not the final intensity or distribution of lesions in scrapie pathology. JC Manson, AR Clarke, PA McBride, I McConnell, J Hope Neurodegeneration: a journal for neurodegenerative disorders …, 1994 | 342 | 1994 |
