Prati
Yougan CHENG
Yougan CHENG
Director, Quantitative Systems Pharmacology, Daiichi Sankyo, Inc.
Potvrđena adresa e-pošte na case.edu - Početna stranica
Naslov
Citirano
Citirano
Godina
QSP toolbox: computational implementation of integrated workflow components for deploying multi-scale mechanistic models
Y Cheng, CJ Thalhauser, S Smithline, J Pagidala, M Miladinov, ...
The AAPS journal 19, 1002-1016, 2017
472017
Double reweighted sparse regression and graph regularization for hyperspectral unmixing
S Wang, TZ Huang, XL Zhao, G Liu, Y Cheng
Remote Sensing 10 (7), 1046, 2018
322018
A Model for Direction Sensing in Dictyostelium discoideum: Ras Activity and Symmetry Breaking Driven by a Gβγ-Mediated, Gα2-Ric8 -- Dependent Signal …
Y Cheng, H Othmer
PLoS computational biology 12 (5), e1004900, 2016
272016
A spatially distributed computational model of brain cellular metabolism
D Calvetti, Y Cheng, E Somersalo
Journal of theoretical biology 376, 48-65, 2015
272015
The Metabolism of Neurons and Astrocytes Through Mathematical Models
E Somersalo, Y Cheng, D Calvetti
Annals of Biomedical Engineering, 1-17, 2012
262012
The roles of signaling in cytoskeletal changes, random movement, direction-sensing and polarization of eukaryotic cells
Y Cheng, B Felix, HG Othmer
Cells 9 (6), 1437, 2020
202020
Virtual populations for quantitative systems pharmacology models
Y Cheng, R Straube, AE Alnaif, L Huang, TA Leil, BJ Schmidt
Systems Medicine, 129-179, 2022
182022
Uncertainty quantification in flux balance analysis of spatially lumped and distributed models of neuron–astrocyte metabolism
D Calvetti, Y Cheng, E Somersalo
Journal of mathematical biology 73, 1823-1849, 2016
102016
Antibodies to Modulate Surface Receptor Systems Are Often Bivalent and Must Compete in a Two‐Dimensional Cell Contact Region
BJ Schmidt, C Bee, M Han, Y Jing, Y Cheng, DJ Tenney, TA Leil
CPT: Pharmacometrics & Systems Pharmacology 8 (12), 873, 2019
42019
Development of a Quantitative Systems Pharmacology (QSP) Toolbox and Virtual Population (VPop) for Affinity-Drug Conjugate (ADC) Research
Y Cheng, HE Vezina, M Gupta, C Pan, TA Leil, BJ Schmidt
J Pharmacokinet Pharmacodynam 43 (1), S47, 2016
22016
Development of a quantitative systems pharmacology (QSP) model to support dose optimization of DS-1103a (anti SIRPa antibody) in combination with trastuzumab deruxtecan in …
Y Cheng, P Vuppala, U Sarma, V Chelliah, P Graaf, T Karibe, S Hayashi, ...
Journal of Clinical Oncology 41 (16_suppl), e14509-e14509, 2023
12023
Computational models of brain energy metabolism at different scales
Y Cheng
Case Western Reserve University, 2014
12014
A phase 1, 2-part, multicenter, first-in-human, dose-escalation and dose-expansion study of DS-1103a with trastuzumab deruxtecan (T-DXd) in patients with advanced solid tumors
L Cavalcante, LL Siu, J Toso, D Mires, R Shiga, J Maruca, G Ayele, ...
Annals of Oncology 34, S333-S333, 2023
2023
Energy Demand and Metabolite Partitioning in Spatially Lumped and Distributed Models of Neuron-Astrocyte Complex
D Calvetti, Y Cheng, E Somersalo
arXiv preprint arXiv:1412.5693, 2014
2014
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