Jeff Brender
A Partially Folded Structure of Amyloid-Beta (1-40) in an Aqueous Environment
S Vivekanandan, JR Brender, SY Lee, A Ramamoorthy
Biochemical and Biophysical Research Communications, 2011
Differences between amyloid-β aggregation in solution and on the membrane: insights into elucidation of the mechanistic details of Alzheimer's disease
SA Kotler, P Walsh, JR Brender, A Ramamoorthy
Chemical Society reviews 43, 6692-6700, 2014
Membrane Disruption and Early Events in the Aggregation of the Diabetes Related Peptide IAPP from a Molecular Perspective
JR Brender, S Salamekh, A Ramamoorthy
Accounts of Chemical Research, 2011
Two-Step Mechanism of Membrane Disruption by A< i> β</i> through Membrane Fragmentation and Pore Formation
MFM Sciacca, SA Kotler, JR Brender, J Chen, D Lee, A Ramamoorthy
Biophysical Journal 103 (4), 702-710, 2012
Determining the effects of lipophilic drugs on membrane structure by solid-state NMR spectroscopy: the case of the antioxidant curcumin
J Barry, M Fritz, JR Brender, PES Smith, DK Lee, A Ramamoorthy
Journal of the American Chemical Society 131 (12), 4490-4498, 2009
Inhibition of Amyloid Peptide Fibrillation by Inorganic Nanoparticles: Functional Similarities with Proteins
SI Yoo, M Yang, JR Brender, V Subramanian, K Sun, NE Joo, SH Jeong, ...
Angewandte Chemie International Edition 50 (22), 5110-5115, 2011
Structure and membrane orientation of IAPP in its natively amidated form at physiological pH in a membrane environment
RPR Nanga, JR Brender, S Vivekanandan, A Ramamoorthy
Biochimica et Biophysica Acta (BBA)-Biomembranes, 2011
Role of zinc in human islet amyloid polypeptide aggregation
JR Brender, K Hartman, RPR Nanga, N Popovych, R de la Salud Bea, ...
Journal of the American Chemical Society 132 (26), 8973-8983, 2010
Amyloid fiber formation and membrane disruption are separate processes localized in two distinct regions of IAPP, the type-2-diabetes-related peptide
JR Brender, EL Lee, MA Cavitt, A Gafni, DG Steel, A Ramamoorthy
Journal of the American Chemical Society 130 (20), 6424-6429, 2008
Insights into antiamyloidogenic properties of the green tea extract (−)-epigallocatechin-3-gallate toward metal-associated amyloid-β species
SJ Hyung, AS DeToma, JR Brender, S Lee, S Vivekanandan, A Kochi, ...
Proceedings of the National Academy of Sciences 110 (10), 3743-3748, 2013
Structures of Rat and Human Islet Amyloid Polypeptide IAPP1− 19 in Micelles by NMR Spectroscopy†
RPR Nanga, JR Brender, J Xu, G Veglia, A Ramamoorthy
Biochemistry 47 (48), 12689-12697, 2008
Rational design of a structural framework with potential use to develop chemical reagents that target and modulate multiple facets of Alzheimer’s disease
S Lee, X Zheng, J Krishnamoorthy, MG Savelieff, HM Park, JR Brender, ...
Journal of the American Chemical Society 136 (1), 299-310, 2014
Induction of negative curvature as a mechanism of cell toxicity by amyloidogenic peptides: the case of islet amyloid polypeptide
PES Smith, JR Brender, A Ramamoorthy
Journal of the American Chemical Society 131 (12), 4470-4478, 2009
Three-dimensional structure and orientation of rat islet amyloid polypeptide protein in a membrane environment by solution NMR spectroscopy
RPR Nanga, JR Brender, J Xu, K Hartman, V Subramanian, ...
Journal of the American Chemical Society 131 (23), 8252-8261, 2009
A Single Mutation in the Nonamyloidogenic Region of Islet Amyloid Polypeptide Greatly Reduces Toxicity†
JR Brender, K Hartman, KR Reid, RT Kennedy, A Ramamoorthy
Biochemistry 47 (48), 12680-12688, 2008
Association of highly compact type II diabetes related islet amyloid polypeptide intermediate species at physiological temperature revealed by diffusion NMR spectroscopy
R Soong, JR Brender, PM Macdonald, A Ramamoorthy
Journal of the American Chemical Society 131 (20), 7079-7085, 2009
Membrane fragmentation by an amyloidogenic fragment of human islet amyloid polypeptide detected by solid-state NMR spectroscopy of membrane nanotubes
JR Brender, UHN Dürr, D Heyl, MB Budarapu, A Ramamoorthy
Biochimica et Biophysica Acta (BBA)-Biomembranes 1768 (9), 2026-2029, 2007
Predicting the effect of mutations on protein-protein binding interactions through structure-based interface profiles
JR Brender, Y Zhang
PLoS computational biology 11 (10), e1004494, 2015
Alternative Pathways of Human Islet Amyloid Polypeptide Aggregation Distinguished by 19F Nuclear Magnetic Resonance-Detected Kinetics of Monomer …
Y Suzuki, JR Brender, K Hartman, A Ramamoorthy, ENG Marsh
Biochemistry 51 (41), 8154-8162, 2012
Frontiers: Does Cholesterol Play a Role in the Bacterial Selectivity of Antimicrobial Peptides?
JR Brender, AJ McHenry, A Ramamoorthy
Frontiers in Molecular Innate Immunity 3, 2012
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