| Structure of the PPARα and-γ ligand binding domain in complex with AZ 242; ligand selectivity and agonist activation in the PPAR family P Cronet, JFW Petersen, R Folmer, N Blomberg, K Sjöblom, U Karlsson, ... Structure 9 (8), 699-706, 2001 | 398 | 2001 |
| Application of fragment-based lead generation to the discovery of novel, cyclic amidine β-secretase inhibitors with nanomolar potency, cellular activity, and high ligand efficiency PD Edwards, JS Albert, M Sylvester, D Aharony, D Andisik, O Callaghan, ... Journal of medicinal chemistry 50 (24), 5912-5925, 2007 | 254 | 2007 |
| Fragment screening to predict druggability (ligandability) and lead discovery success FNB Edfeldt, RHA Folmer, AL Breeze Drug discovery today 16 (7-8), 284-287, 2011 | 232 | 2011 |
| Discovery of a novel warhead against β-secretase through fragment-based lead generation S Geschwindner, LL Olsson, JS Albert, J Deinum, PD Edwards, T de Beer, ... Journal of medicinal chemistry 50 (24), 5903-5911, 2007 | 175 | 2007 |
| Exploitation of structural and regulatory diversity in glutamate racemases T Lundqvist, SL Fisher, G Kern, RHA Folmer, Y Xue, DT Newton, ... Nature 447 (7146), 817-822, 2007 | 165 | 2007 |
| An integrated approach to fragment-based lead generation: philosophy, strategy and case studies from AstraZeneca's drug discovery programmes JS Albert, N Blomberg, AL Breeze, AJH Brown, JN Burrows, PD Edwards, ... Current Topics in Medicinal Chemistry 7 (16), 1600-1629, 2007 | 148 | 2007 |
| Floating stereospecific assignment revisited: application to an 18 kDa protein and comparison with J-coupling data RHA Folmer, CW Hilbers, RNH Konings, M Nilges Journal of biomolecular NMR 9, 245-258, 1997 | 138 | 1997 |
| Solution structure of the M13 major coat protein in detergent micelles: a basis for a model of phage assembly involving specific residues CHM Papavoine, BEC Christiaans, RHA Folmer, RNH Konings, ... Journal of molecular biology 282 (2), 401-419, 1998 | 107 | 1998 |
| Bivalent ligands for protein degradation in drug discovery M Scheepstra, KFW Hekking, L van Hijfte, RHA Folmer Computational and structural biotechnology journal 17, 160-176, 2019 | 106 | 2019 |
| Overcoming the ambiguity problem encountered in the analysis of nuclear Overhauser magnetic resonance spectra of symmetric dimer proteins PJM Folkers, RHA Folmer, RNH Konings, CW Hilbers Journal of the American Chemical Society 115 (9), 3798-3799, 1993 | 103 | 1993 |
| Novel prostaglandin D synthase inhibitors generated by fragment-based drug design M Hohwy, L Spadola, B Lundquist, P Hawtin, J Dahmén, I Groth-Clausen, ... Journal of medicinal chemistry 51 (7), 2178-2186, 2008 | 83 | 2008 |
| A model of the complex between single-stranded DNA and the single-stranded DNA binding protein encoded by gene V of filamentous bacteriophage M13 RHA Folmer, M Nilges, PJM Folkers, RNH Konings, CW Hilbers Journal of molecular biology 240 (4), 341-357, 1994 | 78 | 1994 |
| The solution structure of the Tyr41→ His mutant of the single-stranded DNA binding protein encoded by gene V of the filamentous bacteriophage M13 PJM Folkers, M Nilges, RHA Folmer, RNH Konings, CW Hilbers Journal of molecular biology 236 (1), 229-246, 1994 | 74 | 1994 |
| Drug target residence time: a misleading concept RHA Folmer Drug Discovery Today 23 (1), 12-16, 2018 | 62 | 2018 |
| Integrating biophysics with HTS-driven drug discovery projects RHA Folmer Drug Discovery Today 21 (3), 491-498, 2016 | 58 | 2016 |
| Crystal structure and NMR studies of the apo SH2 domains of ZAP-70: two bikes rather than a tandem RHA Folmer, S Geschwindner, Y Xue Biochemistry 41 (48), 14176-14184, 2002 | 56 | 2002 |
| Solution structure of the single‐stranded DNA binding protein of the filamentous Pseudomonas phage Pf3: similarity to other proteins binding to single‐stranded nucleic acids. RH Folmer, M Nilges, RN Konings, CW Hilbers The EMBO Journal 14 (17), 4132-4142, 1995 | 55 | 1995 |
| Structure of the RTP–DNA complex and the mechanism of polar replication fork arrest JA Wilce, JP Vivian, AF Hastings, G Otting, RHA Folmer, IG Duggin, ... nature structural biology 8 (3), 206-210, 2001 | 51 | 2001 |
| Single-stranded DNA binding protein encoded by the filamentous bacteriophage M13: structural and functional characteristics APM Stassen, RHA Folmer, CW Hilbers, RNH Konings Molecular biology reports 20, 109-127, 1994 | 46 | 1994 |
| A 13C double-filtered NOESY with strongly reduced artefacts and improved sensitivity RHA Folmer, CW Hilbers, RNH Konings, K Hallenga Journal of Biomolecular NMR 5, 427-432, 1995 | 44 | 1995 |
