Convergence of Acquired Mutations and Alternative Splicing of CD19 Enables Resistance to CART-19 ImmunotherapyAlternative Splicing of CD19 Enables Resistance to CART-19 E Sotillo, DM Barrett, KL Black, A Bagashev, D Oldridge, G Wu, ... Cancer discovery 5 (12), 1282-1295, 2015 | 1056 | 2015 |
Anti-CD47 antibody synergizes with rituximab to promote phagocytosis and eradicate non-Hodgkin lymphoma MP Chao, AA Alizadeh, C Tang, JH Myklebust, B Varghese, S Gill, M Jan, ... Cell 142 (5), 699-713, 2010 | 1032 | 2010 |
Human chimeric antigen receptor macrophages for cancer immunotherapy M Klichinsky, M Ruella, O Shestova, XM Lu, A Best, M Zeeman, ... Nature biotechnology 38 (8), 947-953, 2020 | 590 | 2020 |
Dual CD19 and CD123 targeting prevents antigen-loss relapses after CD19-directed immunotherapies M Ruella, DM Barrett, SS Kenderian, O Shestova, TJ Hofmann, ... The Journal of clinical investigation 126 (10), 3814-3826, 2016 | 519 | 2016 |
Induction of resistance to chimeric antigen receptor T cell therapy by transduction of a single leukemic B cell M Ruella, J Xu, DM Barrett, JA Fraietta, TJ Reich, DE Ambrose, ... Nature medicine 24 (10), 1499-1503, 2018 | 463 | 2018 |
Preclinical targeting of human acute myeloid leukemia and myeloablation using chimeric antigen receptor–modified T cells S Gill, SK Tasian, M Ruella, O Shestova, Y Li, DL Porter, M Carroll, ... Blood, The Journal of the American Society of Hematology 123 (15), 2343-2354, 2014 | 462 | 2014 |
Ibrutinib enhances chimeric antigen receptor T-cell engraftment and efficacy in leukemia JA Fraietta, KA Beckwith, PR Patel, M Ruella, Z Zheng, DM Barrett, ... Blood, The Journal of the American Society of Hematology 127 (9), 1117-1127, 2016 | 430 | 2016 |
Going viral: chimeric antigen receptor T‐cell therapy for hematological malignancies S Gill, CH June Immunological reviews 263 (1), 68-89, 2015 | 395 | 2015 |
CD33-specific chimeric antigen receptor T cells exhibit potent preclinical activity against human acute myeloid leukemia SS Kenderian, M Ruella, O Shestova, M Klichinsky, V Aikawa, ... Leukemia 29 (8), 1637-1647, 2015 | 388 | 2015 |
NK cells mediate reduction of GVHD by inhibiting activated, alloreactive T cells while retaining GVT effects JA Olson, DB Leveson-Gower, S Gill, J Baker, A Beilhack, RS Negrin Blood, The Journal of the American Society of Hematology 115 (21), 4293-4301, 2010 | 386 | 2010 |
Genetic inactivation of CD33 in hematopoietic stem cells to enable CAR T cell immunotherapy for acute myeloid leukemia MY Kim, KR Yu, SS Kenderian, M Ruella, S Chen, TH Shin, AA Aljanahi, ... Cell 173 (6), 1439-1453. e19, 2018 | 321 | 2018 |
Chimeric antigen receptor T cell therapy: 25 years in the making S Gill, MV Maus, DL Porter Blood reviews 30 (3), 157-167, 2016 | 253 | 2016 |
Macrophage-Based Approaches for Cancer ImmunotherapyMacrophage-Based Approaches for Cancer Immunotherapy NR Anderson, NG Minutolo, S Gill, M Klichinsky Cancer research 81 (5), 1201-1208, 2021 | 234 | 2021 |
Decade-long leukaemia remissions with persistence of CD4+ CAR T cells JJ Melenhorst, GM Chen, M Wang, DL Porter, C Chen, MKA Collins, ... Nature 602 (7897), 503-509, 2022 | 226 | 2022 |
Sorafenib promotes graft-versus-leukemia activity in mice and humans through IL-15 production in FLT3-ITD-mutant leukemia cells NR Mathew, F Baumgartner, L Braun, D O'Sullivan, S Thomas, ... Nature medicine 24 (3), 282-291, 2018 | 223 | 2018 |
Efficacy and safety of hydroxychloroquine vs placebo for pre-exposure SARS-CoV-2 prophylaxis among health care workers: a randomized clinical trial BS Abella, EL Jolkovsky, BT Biney, JE Uspal, MC Hyman, I Frank, ... JAMA internal medicine 181 (2), 195-202, 2021 | 194 | 2021 |
Rapid development of exhaustion and down-regulation of eomesodermin limit the antitumor activity of adoptively transferred murine natural killer cells S Gill, AE Vasey, A De Souza, J Baker, AT Smith, HE Kohrt, M Florek, ... Blood, The Journal of the American Society of Hematology 119 (24), 5758-5768, 2012 | 187 | 2012 |
Impaired death receptor signaling in leukemia causes antigen-independent resistance by inducing CAR T-cell DysfunctionDeath Receptor–impaired tumors cause CAR T-cell failure N Singh, YG Lee, O Shestova, P Ravikumar, KE Hayer, SJ Hong, XM Lu, ... Cancer discovery 10 (4), 552-567, 2020 | 174 | 2020 |
The Addition of the BTK Inhibitor Ibrutinib to Anti-CD19 Chimeric Antigen Receptor T Cells (CART19) Improves Responses against Mantle Cell LymphomaCombination of CART19 and … M Ruella, SS Kenderian, O Shestova, JA Fraietta, S Qayyum, Q Zhang, ... Clinical Cancer Research 22 (11), 2684-2696, 2016 | 173 | 2016 |
Optimized depletion of chimeric antigen receptor T cells in murine xenograft models of human acute myeloid leukemia SK Tasian, SS Kenderian, F Shen, M Ruella, O Shestova, M Kozlowski, ... Blood, The Journal of the American Society of Hematology 129 (17), 2395-2407, 2017 | 150 | 2017 |