Dr Andrew W Nicholls
Dr Andrew W Nicholls
Executive Director and Head of Bioimaging, GlaxoSmithKline
Potvrđena adresa e-pošte na
Proposed minimum reporting standards for chemical analysis: chemical analysis working group (CAWG) metabolomics standards initiative (MSI)
LW Sumner, A Amberg, D Barrett, MH Beale, R Beger, CA Daykin, ...
Metabolomics 3, 211-221, 2007
Procedures for large-scale metabolic profiling of serum and plasma using gas chromatography and liquid chromatography coupled to mass spectrometry
WB Dunn, D Broadhurst, P Begley, E Zelena, S Francis-McIntyre, ...
Nature protocols 6 (7), 1060-1083, 2011
Integrated metabonomic analysis of the multiorgan effects of hydrazine toxicity in the rat
S Garrod, ME Bollard, AW Nicholls, SC Connor, J Connelly, JK Nicholson, ...
Chemical research in toxicology 18 (2), 115-122, 2005
The importance of experimental design and QC samples in large-scale and MS-driven untargeted metabolomic studies of humans
WB Dunn, ID Wilson, AW Nicholls, D Broadhurst
Bioanalysis 4 (18), 2249-2264, 2012
Chemometric models for toxicity classification based on NMR spectra of biofluids
E Holmes, AW Nicholls, JC Lindon, SC Connor, JC Connelly, ...
Chemical research in toxicology 13 (6), 471-478, 2000
Nuclear magnetic resonance spectroscopic and principal components analysis investigations into biochemical effects of three model hepatotoxins
BM Beckwith-Hall, JK Nicholson, AW Nicholls, PJD Foxall, JC Lindon, ...
Chemical research in toxicology 11 (4), 260-272, 1998
Novel gut-based pharmacology of metformin in patients with type 2 diabetes mellitus
A Napolitano, S Miller, AW Nicholls, D Baker, S Van Horn, E Thomas, ...
PloS one 9 (7), e100778, 2014
Development of a model for classification of toxin‐induced lesions using 1H NMR spectroscopy of urine combined with pattern recognition
E Holmes, AW Nicholls, JC Lindon, S Ramos, M Spraul, P Neidig, ...
NMR in Biomedicine 11 (4‐5), 235-244, 1998
NMR spectroscopic-based metabonomic studies of urinary metabolite variation in acclimatizing germ-free rats
AW Nicholls, RJ Mortishire-Smith, JK Nicholson
Chemical research in toxicology 16 (11), 1395-1404, 2003
Metabonomic investigations into hydrazine toxicity in the rat
AW Nicholls, E Holmes, JC Lindon, JP Shockcor, RD Farrant, ...
Chemical research in toxicology 14 (8), 975-987, 2001
Molecular phenotyping of a UK population: defining the human serum metabolome
WB Dunn, W Lin, D Broadhurst, P Begley, M Brown, E Zelena, ...
Metabolomics 11, 9-26, 2015
The identification of novel biomarkers of renal toxicity using automatic data reduction techniques and PCA of proton NMR spectra of urine
E Holmes, JK Nicholson, AW Nicholls, JC Lindon, SC Connor, S Polley, ...
Chemometrics and Intelligent Laboratory Systems 44 (1-2), 245-255, 1998
Use of metabonomics to identify impaired fatty acid metabolism as the mechanism of a drug-induced toxicity
RJ Mortishire-Smith, GL Skiles, JW Lawrence, S Spence, AW Nicholls, ...
Chemical research in toxicology 17 (2), 165-173, 2004
Comparative metabonomics of differential hydrazine toxicity in the rat and mouse
ME Bollard, HC Keun, O Beckonert, TMD Ebbels, H Antti, AW Nicholls, ...
Toxicology and applied pharmacology 204 (2), 135-151, 2005
Metabolomics as a functional genomic tool for understanding lipid dysfunction in diabetes, obesity and related disorders
JL Griffin, AW Nicholls
Pharmacogenomics 7 (7), 1095-1107, 2006
A metabonomic approach to the investigation of drug-induced phospholipidosis: an NMR spectroscopy and pattern recognition study
AW Nicholls, JK Nicholson, JN Haselden, CJ Waterfield
Biomarkers 5 (6), 410-423, 2000
Automatic alignment of individual peaks in large high-resolution spectral data sets
R Stoyanova, AW Nicholls, JK Nicholson, JC Lindon, TR Brown
Journal of Magnetic Resonance 170 (2), 329-335, 2004
The contrasting roles of PPARδ and PPARγ in regulating the metabolic switch between oxidation and storage of fats in white adipose tissue
LD Roberts, AJ Murray, D Menassa, T Ashmore, AW Nicholls, JL Griffin
Genome Biology 12 (8), R75, 2011
Metabolic phenotyping of a model of adipocyte differentiation
LD Roberts, S Virtue, A Vidal-Puig, AW Nicholls, JL Griffin
Physiological genomics 39 (2), 109-119, 2009
Genome-Wide Association Study of Metabolic Traits Reveals Novel Gene-Metabolite-Disease Links
R Rueedi, M Ledda, AW Nicholls, et al
PLoS Genetics 10 (2), e1004132, 2014
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