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Robert Manguso
Robert Manguso
Broad Institute of MIT and Harvard/ MGH Cancer Center
Potvrđena adresa e-pošte na broadinstitute.org - Početna stranica
Naslov
Citirano
Citirano
Godina
Subsets of exhausted CD8+ T cells differentially mediate tumor control and respond to checkpoint blockade
BC Miller, DR Sen, R Al Abosy, K Bi, YV Virkud, MW LaFleur, KB Yates, ...
Nature immunology 20 (3), 326-336, 2019
13492019
In vivo CRISPR screening identifies Ptpn2 as a cancer immunotherapy target
RT Manguso, HW Pope, MD Zimmer, FD Brown, KB Yates, BC Miller, ...
Nature 547 (7664), 413-418, 2017
9762017
PD-L1 on tumor cells is sufficient for immune evasion in immunogenic tumors and inhibits CD8 T cell cytotoxicity
VR Juneja, KA McGuire, RT Manguso, MW LaFleur, N Collins, ...
Journal of Experimental Medicine 214 (4), 895-904, 2017
7892017
Loss of ADAR1 in tumours overcomes resistance to immune checkpoint blockade
JJ Ishizuka, RT Manguso, CK Cheruiyot, K Bi, A Panda, A Iracheta-Vellve, ...
Nature 565 (7737), 43-48, 2019
4982019
Epigenetic silencing by SETDB1 suppresses tumour intrinsic immunogenicity
GK Griffin, J Wu, A Iracheta-Vellve, JC Patti, J Hsu, T Davis, D Dele-Oni, ...
Nature 595 (7866), 309-314, 2021
2112021
An expanded universe of cancer targets
WC Hahn, JS Bader, TP Braun, A Califano, PA Clemons, BJ Druker, ...
Cell 184 (5), 1142-1155, 2021
1532021
EB1 and EB3 promote cilia biogenesis by several centrosome-related mechanisms
JM Schrøder, J Larsen, Y Komarova, A Akhmanova, RI Thorsteinsson, ...
Journal of cell science 124 (15), 2539-2551, 2011
1052011
Primary cilia and aberrant cell signaling in epithelial ovarian cancer
DL Egeberg, M Lethan, R Manguso, L Schneider, A Awan, TS Jørgensen, ...
Cilia 1, 1-17, 2012
992012
In vivo CRISPR screens reveal the landscape of immune evasion pathways across cancer
J Dubrot, PP Du, SK Lane-Reticker, EA Kessler, AJ Muscato, A Mehta, ...
Nature Immunology 23 (10), 1495-1506, 2022
692022
Mutant IDH inhibits IFNγ–TET2 signaling to promote immunoevasion and tumor maintenance in cholangiocarcinoma
MJ Wu, L Shi, J Dubrot, J Merritt, V Vijay, TY Wei, E Kessler, KE Olander, ...
Cancer discovery 12 (3), 812-835, 2022
572022
In vivo screens using a selective CRISPR antigen removal lentiviral vector system reveal immune dependencies in renal cell carcinoma
J Dubrot, SK Lane-Reticker, EA Kessler, A Ayer, G Mishra, CH Wolfe, ...
Immunity 54 (3), 571-585. e6, 2021
562021
Functional genomics identifies metabolic vulnerabilities in pancreatic cancer
DE Biancur, KS Kapner, K Yamamoto, RS Banh, JE Neggers, ASW Sohn, ...
Cell metabolism 33 (1), 199-210. e8, 2021
552021
TISMO: syngeneic mouse tumor database to model tumor immunity and immunotherapy response
Z Zeng, CJ Wong, L Yang, N Ouardaoui, D Li, W Zhang, S Gu, Y Zhang, ...
Nucleic acids research 50 (D1), D1391-D1397, 2022
512022
Targeting TBK1 to overcome resistance to cancer immunotherapy
Y Sun, O Revach, S Anderson, EA Kessler, CH Wolfe, A Jenney, CE Mills, ...
Nature 615 (7950), 158-167, 2023
362023
PI3K activation allows immune evasion by promoting an inhibitory myeloid tumor microenvironment
NB Collins, R Al Abosy, BC Miller, K Bi, Q Zhao, M Quigley, JJ Ishizuka, ...
Journal for ImmunoTherapy of Cancer 10 (3), 2022
262022
Extracellular matrix proteins regulate NK cell function in peripheral tissues
MD Bunting, M Vyas, M Requesens, A Langenbucher, EB Schiferle, ...
Science advances 8 (11), eabk3327, 2022
222022
The PTPN2/PTPN1 inhibitor ABBV-CLS-484 unleashes potent anti-tumour immunity
CK Baumgartner, H Ebrahimi-Nik, A Iracheta-Vellve, KM Hamel, ...
Nature 622 (7984), 850-862, 2023
212023
Checkpoint blockade-induced CD8+ T cell differentiation in head and neck cancer responders
L Zhou, Z Zeng, AM Egloff, F Zhang, F Guo, KM Campbell, P Du, J Fu, ...
Journal for immunotherapy of cancer 10 (1), 2022
202022
Tumor-derived PGE2 gives NK cells a headache
NH Knudsen, RT Manguso
Immunity 53 (6), 1131-1132, 2020
132020
31st annual meeting and associated programs of the society for immunotherapy of cancer (Sitc 2016): Part two: National harbor, md, USA. 9-13 November 2016
C Ager, M Reilley, C Nicholas, T Bartkowiak, A Jaiswal, M Curran, ...
Journal for ImmunoTherapy of Cancer 4, 107-221, 2016
122016
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