Nataliya Popovych, Ph.D.
Nataliya Popovych, Ph.D.
Principal Scientific Researcher at Genentech
Potvrđena adresa e-pošte na - Početna stranica
Dynamically driven protein allostery
N Popovych, S Sun, RH Ebright, CG Kalodimos
Nature structural & molecular biology 13 (9), 831-838, 2006
Role of zinc in human islet amyloid polypeptide aggregation
JR Brender, K Hartman, RPR Nanga, N Popovych, R de la Salud Bea, ...
Journal of the American Chemical Society 132 (26), 8973-8983, 2010
Phosphorylation and linear ubiquitin direct A20 inhibition of inflammation
IE Wertz, K Newton, D Seshasayee, S Kusam, C Lam, J Zhang, ...
Nature 528 (7582), 370-375, 2015
Structural basis for cAMP-mediated allosteric control of the catabolite activator protein
N Popovych, SR Tzeng, M Tonelli, RH Ebright, CG Kalodimos
Proceedings of the National Academy of Sciences 106 (17), 6927-6932, 2009
A model of the membrane-bound cytochrome b5-cytochrome P450 complex from NMR and mutagenesis data
S Ahuja, N Jahr, SC Im, S Vivekanandan, N Popovych, SV Le Clair, ...
Journal of Biological Chemistry 288 (30), 22080-22095, 2013
Site specific interaction of the polyphenol EGCG with the SEVI amyloid precursor peptide PAP (248–286)
N Popovych, JR Brender, R Soong, S Vivekanandan, K Hartman, ...
The Journal of Physical Chemistry B 116 (11), 3650-3658, 2012
Reactive-site-centric chemoproteomics identifies a distinct class of deubiquitinase enzymes
DS Hewings, J Heideker, TP Ma, AP AhYoung, F El Oualid, A Amore, ...
Nature Communications 9 (1), 1162, 2018
Bacterial curli protein promotes the conversion of PAP248-286 into the amyloid SEVI: cross-seeding of dissimilar amyloid sequences
K Hartman, JR Brender, K Monde, A Ono, ML Evans, N Popovych, ...
PeerJ 1, e5, 2013
NMR Structure in a Membrane Environment Reveals Putative Amyloidogenic Regions of the SEVI Precursor Peptide PAP248−286
RPR Nanga, JR Brender, S Vivekanandan, N Popovych, A Ramamoorthy
Journal of the American Chemical Society 131 (49), 17972-17979, 2009
Probing the transmembrane structure and dynamics of microsomal NADPH-cytochrome P450 oxidoreductase by solid-state NMR
R Huang, K Yamamoto, M Zhang, N Popovych, I Hung, SC Im, Z Gan, ...
Biophysical journal 106 (10), 2126-2133, 2014
The amyloidogenic SEVI precursor, PAP248-286, is highly unfolded in solution despite an underlying helical tendency
JR Brender, RPR Nanga, N Popovych, R Soong, PM Macdonald, ...
Biochimica et Biophysica Acta (BBA)-Biomembranes 1808 (4), 1161-1169, 2011
Targeted degradation via direct 26S proteasome recruitment
C Bashore, S Prakash, MC Johnson, RJ Conrad, IA Kekessie, SJ Scales, ...
Nature Chemical Biology 19 (1), 55-63, 2023
Incorporating NOE-derived distances in conformer generation of cyclic peptides with distance geometry
S Wang, K Krummenacher, GA Landrum, BD Sellers, P Di Lello, ...
Journal of Chemical Information and Modeling 62 (3), 472-485, 2022
A multifaceted hit-finding approach reveals novel LC3 family ligands
M Steffek, E Helgason, N Popovych, L Rougé, JM Bruning, KS Li, ...
Biochemistry 62 (3), 633-644, 2022
Diagnosing and mitigating method-based avidity artifacts that confound polyubiquitin-binding assays
AJ Schoeffler, E Helgason, N Popovych, EC Dueber
Biophysical Reports 1 (2), 2021
Membrane Permeability in a Large Macrocyclic Peptide Driven by a Saddle-Shaped Conformation
JH Faris, E Adaligil, N Popovych, S Ono, M Takahashi, H Nguyen, E Plise, ...
Journal of the American Chemical Society, 2024
Diagnosing and mitigating method-based avidity artifacts that confound polyubiquitin-binding assays
AJ Schoeffler, E Helgason, N Popovych, EC Dueber
Biophysical Reports 2 (2), 2022
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