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Cytochrome P-450 hPCN3, a Novel Cytochrome P-450 IIIA Gene Product That Is Differentially Expressed in Adult Human Liver: cDNA and deduced amino acid sequence and distinct … T Aoyama, S Yamano, DJ Waxman, DP Lapenson, UA Meyer, V Fischer, ... Journal of Biological Chemistry 264 (18), 10388-10395, 1989 | 586 | 1989 |
Nicotine metabolism defect reduces smoking ML Pianezza, EM Sellers, RF Tyndale Nature 393 (6687), 750-750, 1998 | 569 | 1998 |
A major role for CYP2A6 in nicotine C-oxidation by human liver microsomes ES Messina, RF Tyndale, EM Sellers Journal of Pharmacology and Experimental Therapeutics 282 (3), 1608-1614, 1997 | 566 | 1997 |
Large-scale association analysis identifies new lung cancer susceptibility loci and heterogeneity in genetic susceptibility across histological subtypes JD McKay, RJ Hung, Y Han, X Zong, R Carreras-Torres, DC Christiani, ... Nature genetics 49 (7), 1126-1132, 2017 | 459 | 2017 |
Nicotine metabolite ratio as an index of cytochrome P450 2A6 metabolic activity D Dempsey, P Tutka, P Jacob III, F Allen, K Schoedel, RF Tyndale, ... Clinical Pharmacology & Therapeutics 76 (1), 64-72, 2004 | 457 | 2004 |
Ethnic variation in CYP2A6 and association of genetically slow nicotine metabolism and smoking in adult Caucasians KA Schoedel, EB Hoffmann, Y Rao, EM Sellers, RF Tyndale Pharmacogenetics and Genomics 14 (9), 615-626, 2004 | 355 | 2004 |
Implications of CYP2A6 Genetic Variation for Smoking Behaviors and Nicotine Dependence V Malaiyandi, EM Sellers, RF Tyndale Clinical Pharmacology & Therapeutics 77 (3), 145-158, 2005 | 346 | 2005 |
Nicotine-dependence symptoms are associated with smoking frequency in adolescents J O'Loughlin, J DiFranza, RF Tyndale, G Meshefedjian, E McMillan-Davey, ... American journal of preventive medicine 25 (3), 219-225, 2003 | 334 | 2003 |
Duplications and defects in the CYP2A6 gene: identification, genotyping, and in vivo effects on smoking Y Rao, E Hoffmann, M Zia, L Bodin, M Zeman, EM Sellers, RF Tyndale Molecular pharmacology 58 (4), 747-755, 2000 | 332 | 2000 |
Nicotine metabolite ratio predicts efficacy of transdermal nicotine for smoking cessation C Lerman, R Tyndale, F Patterson, EP Wileyto, PG Shields, A Pinto, ... Clinical Pharmacology & Therapeutics 79 (6), 600-608, 2006 | 326 | 2006 |
The pharmacogenetics research network: from SNP discovery to clinical drug response KM Giacomini, CM Brett, RB Altman, NL Benowitz, ME Dolan, ... Clinical Pharmacology & Therapeutics 81 (3), 328-345, 2007 | 294 | 2007 |
Genetics of alcohol and tobacco use in humans RF Tyndale Annals of medicine 35 (2), 94-121, 2003 | 289 | 2003 |
Inhibition of cytochromes P450 by antifungal imidazole derivatives W Zhang, Y Ramamoorthy, T Kilicarslan, H Nolte, RF Tyndale, EM Sellers Drug Metabolism and Disposition 30 (3), 314-318, 2002 | 285 | 2002 |
Nicotine without smoke: Tobacco harm reduction A Amos, D Arnott, P Aveyard, L Bauld, I Bogdanovica, J Britton, ... Royal College of Physicians, 2016 | 271 | 2016 |
Cytochrome P450 enzymes in the brain: emerging evidence of biological significance CS Ferguson, RF Tyndale Trends in pharmacological sciences 32 (12), 708-714, 2011 | 261 | 2011 |
Use of the nicotine metabolite ratio as a genetically informed biomarker of response to nicotine patch or varenicline for smoking cessation: a randomised, double-blind placebo … C Lerman, RA Schnoll, LW Hawk, P Cinciripini, TP George, EP Wileyto, ... The lancet Respiratory medicine 3 (2), 131-138, 2015 | 257 | 2015 |
CYP2A6 genotype and the metabolism and disposition kinetics of nicotine NL Benowitz, GE Swan, P Jacob III, CN Lessov‐Schlaggar, RF Tyndale Clinical Pharmacology & Therapeutics 80 (5), 457-467, 2006 | 256 | 2006 |
Smoking, alcoholism and genetic polymorphisms alter CYP2B6 levels in human brain S Miksys, C Lerman, PG Shields, DC Mash, RF Tyndale Neuropharmacology 45 (1), 122-132, 2003 | 256 | 2003 |
The dopamine transporter and cytochrome P450IID1 (debrisoquine 4-hydroxylase) in brain: resolution and identification of two distinct [3H] GBR-12935 binding proteins HB Niznik, RF Tyndale, FR Sallee, FJ Gonzalez, JP Hardwick, T Inaba, ... Archives of Biochemistry and Biophysics 276 (2), 424-432, 1990 | 254 | 1990 |