R Tyndale
R Tyndale
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Guidelines on nicotine dose selection for in vivo research
SG Matta, DJ Balfour, NL Benowitz, RT Boyd, JJ Buccafusco, ...
Psychopharmacology 190, 269-319, 2007
Cytochrome P-450 hPCN3, a Novel Cytochrome P-450 IIIA Gene Product That Is Differentially Expressed in Adult Human Liver: cDNA and deduced amino acid sequence and distinct …
T Aoyama, S Yamano, DJ Waxman, DP Lapenson, UA Meyer, V Fischer, ...
Journal of Biological Chemistry 264 (18), 10388-10395, 1989
Nicotine metabolism defect reduces smoking
ML Pianezza, EM Sellers, RF Tyndale
Nature 393 (6687), 750-750, 1998
A major role for CYP2A6 in nicotine C-oxidation by human liver microsomes
ES Messina, RF Tyndale, EM Sellers
Journal of Pharmacology and Experimental Therapeutics 282 (3), 1608-1614, 1997
Large-scale association analysis identifies new lung cancer susceptibility loci and heterogeneity in genetic susceptibility across histological subtypes
JD McKay, RJ Hung, Y Han, X Zong, R Carreras-Torres, DC Christiani, ...
Nature genetics 49 (7), 1126-1132, 2017
Nicotine metabolite ratio as an index of cytochrome P450 2A6 metabolic activity
D Dempsey, P Tutka, P Jacob III, F Allen, K Schoedel, RF Tyndale, ...
Clinical Pharmacology & Therapeutics 76 (1), 64-72, 2004
Ethnic variation in CYP2A6 and association of genetically slow nicotine metabolism and smoking in adult Caucasians
KA Schoedel, EB Hoffmann, Y Rao, EM Sellers, RF Tyndale
Pharmacogenetics and Genomics 14 (9), 615-626, 2004
Implications of CYP2A6 Genetic Variation for Smoking Behaviors and Nicotine Dependence
V Malaiyandi, EM Sellers, RF Tyndale
Clinical Pharmacology & Therapeutics 77 (3), 145-158, 2005
Nicotine-dependence symptoms are associated with smoking frequency in adolescents
J O'Loughlin, J DiFranza, RF Tyndale, G Meshefedjian, E McMillan-Davey, ...
American journal of preventive medicine 25 (3), 219-225, 2003
Duplications and defects in the CYP2A6 gene: identification, genotyping, and in vivo effects on smoking
Y Rao, E Hoffmann, M Zia, L Bodin, M Zeman, EM Sellers, RF Tyndale
Molecular pharmacology 58 (4), 747-755, 2000
Nicotine metabolite ratio predicts efficacy of transdermal nicotine for smoking cessation
C Lerman, R Tyndale, F Patterson, EP Wileyto, PG Shields, A Pinto, ...
Clinical Pharmacology & Therapeutics 79 (6), 600-608, 2006
The pharmacogenetics research network: from SNP discovery to clinical drug response
KM Giacomini, CM Brett, RB Altman, NL Benowitz, ME Dolan, ...
Clinical Pharmacology & Therapeutics 81 (3), 328-345, 2007
Genetics of alcohol and tobacco use in humans
RF Tyndale
Annals of medicine 35 (2), 94-121, 2003
Inhibition of cytochromes P450 by antifungal imidazole derivatives
W Zhang, Y Ramamoorthy, T Kilicarslan, H Nolte, RF Tyndale, EM Sellers
Drug Metabolism and Disposition 30 (3), 314-318, 2002
Nicotine without smoke: Tobacco harm reduction
A Amos, D Arnott, P Aveyard, L Bauld, I Bogdanovica, J Britton, ...
Royal College of Physicians, 2016
Cytochrome P450 enzymes in the brain: emerging evidence of biological significance
CS Ferguson, RF Tyndale
Trends in pharmacological sciences 32 (12), 708-714, 2011
Use of the nicotine metabolite ratio as a genetically informed biomarker of response to nicotine patch or varenicline for smoking cessation: a randomised, double-blind placebo …
C Lerman, RA Schnoll, LW Hawk, P Cinciripini, TP George, EP Wileyto, ...
The lancet Respiratory medicine 3 (2), 131-138, 2015
CYP2A6 genotype and the metabolism and disposition kinetics of nicotine
NL Benowitz, GE Swan, P Jacob III, CN Lessov‐Schlaggar, RF Tyndale
Clinical Pharmacology & Therapeutics 80 (5), 457-467, 2006
Smoking, alcoholism and genetic polymorphisms alter CYP2B6 levels in human brain
S Miksys, C Lerman, PG Shields, DC Mash, RF Tyndale
Neuropharmacology 45 (1), 122-132, 2003
The dopamine transporter and cytochrome P450IID1 (debrisoquine 4-hydroxylase) in brain: resolution and identification of two distinct [3H] GBR-12935 binding proteins
HB Niznik, RF Tyndale, FR Sallee, FJ Gonzalez, JP Hardwick, T Inaba, ...
Archives of Biochemistry and Biophysics 276 (2), 424-432, 1990
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