Sumit Prakash
Sumit Prakash
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An unstructured initiation site is required for efficient proteasome-mediated degradation
S Prakash, L Tian, KS Ratliff, RE Lehotzky, A Matouschek
Nature structural & molecular biology 11 (9), 830-837, 2004
ATP-dependent proteases degrade their substrates by processively unraveling them from the degradation signal
C Lee, MP Schwartz, S Prakash, M Iwakura, A Matouschek
Molecular cell 7 (3), 627-637, 2001
USP7 small-molecule inhibitors interfere with ubiquitin binding
L Kategaya, P Di Lello, L Rougé, R Pastor, KR Clark, J Drummond, ...
Nature 550 (7677), 534-538, 2017
Lack of a robust unfoldase activity confers a unique level of substrate specificity to the universal AAA protease FtsH
C Herman, S Prakash, CZ Lu, A Matouschek, CA Gross
Molecular cell 11 (3), 659-669, 2003
Ubiquitination in the regulation of inflammatory cell death and cancer
PE Cockram, M Kist, S Prakash, SH Chen, IE Wertz, D Vucic
Cell Death & Differentiation 28 (2), 591-605, 2021
Defining the geometry of the two-component proteasome degron
T Inobe, S Fishbain, S Prakash, A Matouschek
Nature chemical biology 7 (3), 161-167, 2011
Protein unfolding in the cell
S Prakash, A Matouschek
Trends in biochemical sciences 29 (11), 593-600, 2004
Substrate selection by the proteasome during degradation of protein complexes
S Prakash, T Inobe, AJ Hatch, A Matouschek
Nature chemical biology 5 (1), 29-36, 2009
Controlling a single protein in a nanopore through electrostatic traps
Mohammad, S Prakash, A Matouschek, L Movileanu
Journal of the American Chemical Society 130 (12), 4081-4088, 2008
Rad23 escapes degradation because it lacks a proteasome initiation region
S Fishbain, S Prakash, A Herrig, S Elsasser, A Matouschek
Nature communications 2 (1), 192, 2011
Concurrent translocation of multiple polypeptide chains through the proteasomal degradation channel
C Lee, S Prakash, A Matouschek
Journal of Biological Chemistry 277 (38), 34760-34765, 2002
ATP-dependent proteases differ substantially in their ability to unfold globular proteins
P Koodathingal, NE Jaffe, DA Kraut, S Prakash, S Fishbain, C Herman, ...
Journal of Biological Chemistry 284 (28), 18674-18684, 2009
Targeted degradation via direct 26S proteasome recruitment
C Bashore, S Prakash, MC Johnson, RJ Conrad, IA Kekessie, SJ Scales, ...
Nature Chemical Biology 19 (1), 55-63, 2023
Allosteric N-WASP activation by an inter-SH3 domain linker in Nck
J Okrut, S Prakash, Q Wu, MJS Kelly, J Taunton
Proceedings of the National Academy of Sciences 112 (47), E6436-E6445, 2015
To degrade or release: ubiquitin-chain remodeling
DA Kraut, S Prakash, A Matouschek
Trends in cell biology 17 (9), 419-421, 2007
Primary amine tethered small molecules promote the degradation of X-linked inhibitor of apoptosis protein
W den Besten, K Verma, S Yamazoe, N Blaquiere, W Phung, ...
Journal of the American Chemical Society 143 (28), 10571-10575, 2021
Constitutive protein degradation induces acute cell death via proteolysis products
SH Chen, S Prakash, E Helgason, CL Gilchrist, LR Kenner, R Srinivasan, ...
bioRxiv, 2023.02. 06.527237, 2023
After load reduction therapy with nitroprusside in chronic severe aortic regurgitation. A non invasive assessment.
M Durairaj, SN Handekar, HL Kher, S Prakash, GR Narayanan
Indian heart j, 1980
Prevalence of hypertension with reversible risk factors in railway employees–A sample report
CK Das, S Prakash, P Barapatre, AK Das, MM Pathak, G Chakraborty
Indian Heart Journal 70, S11, 2018
Multifaceted presentations of ictal syncope
CK Das, A Minz, S Prakash, MS Tripathy, GK Chakraborty
Indian Heart Journal 70, S87, 2018
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