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Ben Small
Ben Small
PK/PD Scientist
Verified email at certara.com
Title
Cited by
Cited by
Year
Optimisation and validation of a medium-throughput electrophysiology-based hERG assay using IonWorks™ HT
MH Bridgland-Taylor, AC Hargreaves, A Easter, A Orme, DC Henthorn, ...
Journal of pharmacological and toxicological methods 54 (2), 189-199, 2006
1792006
Development of a multicompartment permeability‐limited lung PBPK model and its application in predicting pulmonary pharmacokinetics of antituberculosis drugs
L Gaohua, J Wedagedera, BG Small, L Almond, K Romero, D Hermann, ...
CPT: pharmacometrics & systems pharmacology 4 (10), 605-613, 2015
922015
Efficient discovery of anti-inflammatory small-molecule combinations using evolutionary computing
BG Small, BW McColl, R Allmendinger, J Pahle, G López-Castejón, ...
Nature Chemical Biology 7 (12), 902-908, 2011
772011
Optimisation and validation of a medium-throughput electrophysiology-based hNav1. 5 assay using IonWorks™
AR Harmer, N Abi-Gerges, A Easter, A Woods, CL Lawrence, BG Small, ...
Journal of pharmacological and toxicological methods 57 (1), 30-41, 2008
682008
LY339434, a GluR5 kainate receptor agonist
B Small, J Thomas, M Kemp, K Hoo, B Ballyk, M Deverill, AM Ogden, ...
Neuropharmacology 37 (10-11), 1261-1267, 1998
531998
Evidence for gender differences in electrophysiological properties of canine Purkinje fibres
N Abi‐Gerges, BG Small, CL Lawrence, TG Hammond, JP Valentin, ...
British journal of pharmacology 142 (8), 1255-1264, 2004
482004
Gender differences in the slow delayed (IKs) but not in inward (IK1) rectifier K+ currents of canine Purkinje fibre cardiac action potential: key roles for IKs, β‐adrenoceptor …
N Abi‐Gerges, BG Small, CL Lawrence, TG Hammond, JP Valentin, ...
British journal of pharmacology 147 (6), 653-660, 2006
422006
Increasing application of pediatric physiologically based pharmacokinetic models across academic and industry organizations
TN Johnson, BG Small, K Rowland Yeo
CPT: Pharmacometrics & Systems Pharmacology 11 (3), 373-383, 2022
372022
Integration of omics data sources to inform mechanistic modeling of immune‐oncology therapies: a tutorial for clinical pharmacologists
G Lazarou, V Chelliah, BG Small, M Walker, PH van der Graaf, ...
Clinical Pharmacology & Therapeutics 107 (4), 858-870, 2020
312020
Validation of a voltage-sensitive dye (di-4-ANEPPS)-based method for assessing drug-induced delayed repolarisation in beagle dog left ventricular midmyocardial myocytes
MEL Hardy, CE Pollard, BG Small, M Bridgland-Taylor, AJ Woods, ...
Journal of pharmacological and toxicological methods 60 (1), 94-106, 2009
282009
Prediction of liver volume–a population‐based approach to meta‐analysis of paediatric, adult and geriatric populations–an update
BG Small, B Wendt, M Jamei, TN Johnson
Biopharmaceutics & drug disposition 38 (4), 290-300, 2017
242017
A quantitative systems pharmacology consortium approach to managing immunogenicity of therapeutic proteins
AM Kierzek, TP Hickling, I Figueroa, JC Kalvass, M Nijsen, K Mohan, ...
CPT: Pharmacometrics & Systems Pharmacology 8 (11), 773, 2019
232019
Early assessment of proarrhythmic risk of drugs using the in vitro data and single-cell-based in silico models: proof of concept
M Abbasi, BG Small, N Patel, M Jamei, S Polak
Toxicology Mechanisms and Methods 27 (2), 88-99, 2017
182017
A best practice framework for applying physiologically‐based pharmacokinetic modeling to pediatric drug development
TN Johnson, BG Small, EG Berglund, K Rowland Yeo
CPT: Pharmacometrics & Systems Pharmacology 10 (9), 967-972, 2021
132021
Development of physiologically‐based pharmacokinetic models for standard of care and newer tuberculosis drugs
H Humphries, L Almond, A Berg, I Gardner, O Hatley, X Pan, B Small, ...
CPT: Pharmacometrics & Systems Pharmacology 10 (11), 1382-1395, 2021
102021
Development and application of a pediatric mechanistic kidney model
F Salem, BG Small, TN Johnson
CPT: Pharmacometrics & Systems Pharmacology 11 (7), 854-866, 2022
92022
Development of a Multicompartment Permeability-Limited Lung PBPK Model and Its Application in Predicting Pulmonary Pharmacokinetics of Antituberculosis Drugs. CPT …
L Gaohua, J Wedagedera, BG Small, L Almond, K Romero, D Hermann, ...
8
Another step toward qualification of pediatric physiologically based pharmacokinetic models to facilitate inclusivity and diversity in pediatric clinical studies
BG Small, TN Johnson, K Rowland Yeo
Clinical Pharmacology & Therapeutics 113 (3), 735-745, 2023
72023
LY339434, a GluR5-selective kainate receptor agonist
BG Small, SR Baker, A Rubio, EF Sharpe, BA Ballyk, K Hoo, A Mandelzys, ...
BRITISH JOURNAL OF PHARMACOLOGY 122, 59P-59P, 1997
51997
Development of a novel multi-compartment granuloma model to predict local drug distribution and its impact on pharmacodynamics and disease progression in tuberculosis
RH Rose, L Gaohua, J Wedagedera, BG Small, A Barnett, K Romero, ...
Population Approach Group in Europe (PAGE) Annual Meeting, Lisbon, Portugal, 2016
32016
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Articles 1–20