| Optimized sgRNA design to maximize activity and minimize off-target effects of CRISPR-Cas9 JG Doench, N Fusi, M Sullender, M Hegde, EW Vaimberg, KF Donovan, ... Nature biotechnology 34 (2), 184-191, 2016 | 2912 | 2016 |
| HIV: cell binding and entry CB Wilen, JC Tilton, RW Doms Cold Spring Harbor perspectives in medicine 2 (8), a006866, 2012 | 848 | 2012 |
| Neuroinvasion of SARS-CoV-2 in human and mouse brain E Song, C Zhang, B Israelow, A Lu-Culligan, AV Prado, S Skriabine, P Lu, ... Journal of Experimental Medicine 218 (3), 2021 | 660 | 2021 |
| Phenotypic properties of transmitted founder HIV-1 NF Parrish, F Gao, H Li, EE Giorgi, HJ Barbian, EH Parrish, L Zajic, ... Proceedings of the National Academy of Sciences 110 (17), 6626-6633, 2013 | 434 | 2013 |
| Altered virome and bacterial microbiome in human immunodeficiency virus-associated acquired immunodeficiency syndrome CL Monaco, DB Gootenberg, G Zhao, SA Handley, MS Ghebremichael, ... Cell host & microbe 19 (3), 311-322, 2016 | 346 | 2016 |
| Genome-wide CRISPR screens reveal host factors critical for SARS-CoV-2 infection J Wei, MM Alfajaro, PC DeWeirdt, RE Hanna, WJ Lu-Culligan, WL Cai, ... Cell 184 (1), 76-91. e13, 2021 | 320 | 2021 |
| Mouse model of SARS-CoV-2 reveals inflammatory role of type I interferon signaling B Israelow, E Song, T Mao, P Lu, A Meir, F Liu, MM Alfajaro, J Wei, ... Journal of Experimental Medicine 217 (12), 2020 | 302 | 2020 |
| Molecular mechanisms of HIV entry CB Wilen, JC Tilton, RW Doms Viral molecular machines, 223-242, 2012 | 256 | 2012 |
| Discovery of a proteinaceous cellular receptor for a norovirus RC Orchard, CB Wilen, JG Doench, MT Baldridge, BT McCune, YCJ Lee, ... Science 353 (6302), 933-936, 2016 | 247 | 2016 |
| Simultaneous zinc-finger nuclease editing of the HIV coreceptors ccr5 and cxcr4 protects CD4+ T cells from HIV-1 infection CA Didigu, CB Wilen, J Wang, J Duong, AJ Secreto, GA Danet-Desnoyers, ... Blood, The Journal of the American Society of Hematology 123 (1), 61-69, 2014 | 185 | 2014 |
| Transmitted/founder and chronic subtype C HIV-1 use CD4 and CCR5 receptors with equal efficiency and are not inhibited by blocking the integrin α4β7 NF Parrish, CB Wilen, LB Banks, SS Iyer, JM Pfaff, JF Salazar-Gonzalez, ... PLoS pathogens 8 (5), e1002686, 2012 | 178 | 2012 |
| Engineering HIV-resistant human CD4+ T cells with CXCR4-specific zinc-finger nucleases CB Wilen, J Wang, JC Tilton, JC Miller, KA Kim, EJ Rebar, SA Sherrill-Mix, ... PLoS pathogens 7 (4), e1002020, 2011 | 174 | 2011 |
| Single-cell longitudinal analysis of SARS-CoV-2 infection in human airway epithelium identifies target cells, alterations in gene expression, and cell state changes NG Ravindra, MM Alfajaro, V Gasque, NC Huston, H Wan, K Szigeti-Buck, ... PLoS biology 19 (3), e3001143, 2021 | 168* | 2021 |
| Tropism for tuft cells determines immune promotion of norovirus pathogenesis CB Wilen, S Lee, LL Hsieh, RC Orchard, C Desai, BL Hykes Jr, ... Science 360 (6385), 204-208, 2018 | 163 | 2018 |
| Phenotypic and immunologic comparison of clade B transmitted/founder and chronic HIV-1 envelope glycoproteins CB Wilen, NF Parrish, JM Pfaff, JM Decker, EA Henning, H Haim, ... Journal of virology 85 (17), 8514-8527, 2011 | 159 | 2011 |
| Comprehensive in vivo secondary structure of the SARS-CoV-2 genome reveals novel regulatory motifs and mechanisms NC Huston, H Wan, MS Strine, RCA Tavares, CB Wilen, AM Pyle Molecular cell 81 (3), 584-598. e5, 2021 | 152 | 2021 |
| A maraviroc-resistant HIV-1 with narrow cross-resistance to other CCR5 antagonists depends on both N-terminal and extracellular loop domains of drug-bound CCR5 JC Tilton, CB Wilen, CA Didigu, R Sinha, JE Harrison, C Agrawal-Gamse, ... Journal of virology 84 (20), 10863-10876, 2010 | 133 | 2010 |
| Acute encephalopathy with elevated CSF inflammatory markers as the initial presentation of COVID-19 S Farhadian, LR Glick, CBF Vogels, J Thomas, J Chiarella, ... BMC neurology 20 (1), 1-5, 2020 | 113 | 2020 |
| Inflammasome activation in infected macrophages drives COVID-19 pathology E Sefik, R Qu, C Junqueira, E Kaffe, H Mirza, J Zhao, JR Brewer, A Han, ... Nature 606 (7914), 585-593, 2022 | 108 | 2022 |
| Translational shutdown and evasion of the innate immune response by SARS-CoV-2 NSP14 protein JCC Hsu, M Laurent-Rolle, JB Pawlak, CB Wilen, P Cresswell Proceedings of the National Academy of Sciences 118 (24), e2101161118, 2021 | 107 | 2021 |
Robert W. DomsChildren's Hospital of PhiladelphiaPotvrđena adresa e-pošte na chop.edu
