Stephen Elledge
Stephen Elledge
Harvard Medical School
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The p21 Cdk-interacting protein Cip1 is a potent inhibitor of G1 cyclin-dependent kinases
JW Harper, GR Adami, N Wei, K Keyomarsi, SJ Elledge
Cell 75 (4), 805-816, 1993
The DNA damage response: making it safe to play with knives
A Ciccia, SJ Elledge
Molecular cell 40 (2), 179-204, 2010
The DNA damage response: putting checkpoints in perspective
BBS Zhou, SJ Elledge
Nature 408 (6811), 433-439, 2000
ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage
S Matsuoka, BA Ballif, A Smogorzewska, ER McDonald III, KE Hurov, ...
science 316 (5828), 1160-1166, 2007
Sensing DNA damage through ATRIP recognition of RPA-ssDNA complexes
L Zou, SJ Elledge
Science 300 (5625), 1542-1548, 2003
WAF1/CIP1 Is Induced in p53-mediated G1 Arrest and Apoptosis
WS El-Deiry, JW Harper, PM O'Connor, VE Velculescu, CE Canman, ...
Cancer research 54 (5), 1169-1174, 1994
Cell cycle checkpoints: preventing an identity crisis
SJ Elledge
Science 274 (5293), 1664-1672, 1996
Mice lacking p21CIP1/WAF1 undergo normal development, but are defective in G1 checkpoint control
C Deng, P Zhang, JW Harper, SJ Elledge, P Leder
Cell 82 (4), 675-684, 1995
Dicer is essential for mouse development
E Bernstein, SY Kim, MA Carmell, EP Murchison, H Alcorn, MZ Li, AA Mills, ...
Nature genetics 35 (3), 215-217, 2003
Principles of cancer therapy: oncogene and non-oncogene addiction
J Luo, NL Solimini, SJ Elledge
Cell 136 (5), 823-837, 2009
Chk1 is an essential kinase that is regulated by Atr and required for the G2/M DNA damage checkpoint
Q Liu, S Guntuku, XS Cui, S Matsuoka, D Cortez, K Tamai, G Luo, ...
Genes & development 14 (12), 1448-1459, 2000
The DNA damage response: ten years after
JW Harper, SJ Elledge
Molecular cell 28 (5), 739-745, 2007
The retinoblastoma protein associates with the protein phosphatase type 1 catalytic subunit.
T Durfee, K Becherer, PL Chen, SH Yeh, Y Yang, AE Kilburn, WH Lee, ...
Genes & development 7 (4), 555-569, 1993
p53-dependent inhibition of cyclin-dependent kinase activities in human fibroblasts during radiation-induced G1 arrest
V Dulić, WK Kaufmann, SJ Wilson, TD Tisty, E Lees, JW Harper, ...
Cell 76 (6), 1013-1023, 1994
A quantitative atlas of mitotic phosphorylation
N Dephoure, C Zhou, J Villén, SA Beausoleil, CE Bakalarski, SJ Elledge, ...
Proceedings of the National Academy of Sciences 105 (31), 10762-10767, 2008
SKP1 connects cell cycle regulators to the ubiquitin proteolysis machinery through a novel motif, the F-box
C Bai, P Sen, K Hofmann, L Ma, M Goebl, JW Harper, SJ Elledge
Cell 86 (2), 263-274, 1996
Identification of host proteins required for HIV infection through a functional genomic screen
AL Brass, DM Dykxhoorn, Y Benita, N Yan, A Engelman, RJ Xavier, ...
science 319 (5865), 921-926, 2008
Linkage of ATM to cell cycle regulation by the Chk2 protein kinase
S Matsuoka, M Huang, SJ Elledge
Science 282 (5395), 1893-1897, 1998
Conservation of the Chk1 checkpoint pathway in mammals: linkage of DNA damage to Cdk regulation through Cdc25
Y Sanchez, C Wong, RS Thoma, R Richman, Z Wu, H Piwnica-Worms, ...
Science 277 (5331), 1497-1501, 1997
Structure of the Cul1–Rbx1–Skp1–F boxSkp2 SCF ubiquitin ligase complex
N Zheng, BA Schulman, L Song, JJ Miller, PD Jeffrey, P Wang, C Chu, ...
Nature 416 (6882), 703-709, 2002
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