Andrew Tutt
Andrew Tutt
Professor of Oncology, Institute of Cancer Research London and Kings College London
Verified email at
Cited by
Cited by
Signatures of mutational processes in human cancer
LB Alexandrov, S Nik-Zainal, DC Wedge, SAJR Aparicio, S Behjati, ...
Nature 500 (7463), 415-421, 2013
Targeting the DNA repair defect in BRCA mutant cells as a therapeutic strategy
H Farmer, N McCabe, CJ Lord, ANJ Tutt, DA Johnson, TB Richardson, ...
Nature 434 (7035), 917-921, 2005
Inhibition of Poly(ADP-Ribose) Polymerase in Tumors from BRCA Mutation Carriers
PC Fong, DS Boss, TA Yap, A Tutt, P Wu, M Mergui-Roelvink, P Mortimer, ...
New England Journal of Medicine 361 (2), 123-134, 2009
Personalizing the treatment of women with early breast cancer: highlights of the St Gallen International Expert Consensus on the Primary Therapy of Early Breast Cancer 2013
A Goldhirsch, EP Winer, AS Coates, RD Gelber, M Piccart-Gebhart, ...
Annals of oncology 24 (9), 2206-2223, 2013
Tailoring therapies—improving the management of early breast cancer: St Gallen International Expert Consensus on the Primary Therapy of Early Breast Cancer 2015
AS Coates, EP Winer, A Goldhirsch, RD Gelber, M Gnant, ...
Annals of oncology 26 (8), 1533-1546, 2015
Oral poly (ADP-ribose) polymerase inhibitor olaparib in patients with BRCA1 or BRCA2 mutations and advanced breast cancer: a proof-of-concept trial
A Tutt, M Robson, JE Garber, SM Domchek, MW Audeh, JN Weitzel, ...
The Lancet 376 (9737), 235-244, 2010
Landscape of somatic mutations in 560 breast cancer whole-genome sequences
S Nik-Zainal, H Davies, J Staaf, M Ramakrishna, D Glodzik, X Zou, ...
Nature 534 (7605), 47-54, 2016
Mutational processes molding the genomes of 21 breast cancers
S Nik-Zainal, LB Alexandrov, DC Wedge, P Van Loo, CD Greenman, ...
Cell 149 (5), 979-993, 2012
Hallmarks of'BRCAness' in sporadic cancers
N Turner, A Tutt, A Ashworth
Nature reviews cancer 4 (10), 814-819, 2004
The landscape of cancer genes and mutational processes in breast cancer
PJ Stephens, PS Tarpey, H Davies, P Van Loo, C Greenman, DC Wedge, ...
Nature 486 (7403), 400-404, 2012
Oral poly (ADP-ribose) polymerase inhibitor olaparib in patients with BRCA1 or BRCA2 mutations and recurrent ovarian cancer: a proof-of-concept trial
MW Audeh, J Carmichael, RT Penson, M Friedlander, B Powell, ...
The lancet 376 (9737), 245-251, 2010
The life history of 21 breast cancers
S Nik-Zainal, P Van Loo, DC Wedge, LB Alexandrov, CD Greenman, ...
Cell 149 (5), 994-1007, 2012
Deficiency in the repair of DNA damage by homologous recombination and sensitivity to poly (ADP-ribose) polymerase inhibition
N McCabe, NC Turner, CJ Lord, K Kluzek, A Białkowska, S Swift, ...
Cancer research 66 (16), 8109-8115, 2006
Triple negative tumours: a critical review
JS Reis‐Filho, ANJ Tutt
Histopathology 52 (1), 108-118, 2008
De-escalating and escalating treatments for early-stage breast cancer: the St. Gallen International Expert Consensus Conference on the Primary Therapy of Early Breast Cancer 2017
G Curigliano, HJ Burstein, EP Winer, M Gnant, P Dubsky, S Loibl, ...
Annals of Oncology 28 (8), 1700-1712, 2017
Poly(ADP)-Ribose Polymerase Inhibition: Frequent Durable Responses in BRCA Carrier Ovarian Cancer Correlating With Platinum-Free Interval
PC Fong, TA Yap, DS Boss, CP Carden, M Mergui-Roelvink, C Gourley, ...
Journal of clinical oncology 28 (15), 2512-2519, 2010
Definition of clinically distinct molecular subtypes in estrogen receptor-positive breast carcinomas through genomic grade
S Loi, B Haibe-Kains, C Desmedt, F Lallemand, AM Tutt, C Gillet, P Ellis, ...
Journal of clinical oncology 25 (10), 1239-1246, 2007
BRCA1 basal-like breast cancers originate from luminal epithelial progenitors and not from basal stem cells
G Molyneux, FC Geyer, FA Magnay, A McCarthy, H Kendrick, R Natrajan, ...
Cell stem cell 7 (3), 403-417, 2010
HRDetect is a predictor of BRCA1 and BRCA2 deficiency based on mutational signatures
H Davies, D Glodzik, S Morganella, LR Yates, J Staaf, X Zou, ...
Nature medicine 23 (4), 517-525, 2017
3rd ESO–ESMO international consensus guidelines for advanced breast cancer (ABC 3)
F Cardoso, A Costa, E Senkus, M Aapro, F André, CH Barrios, J Bergh, ...
The Breast 31, 244-259, 2017
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