Marco Ruella, MD
Convergence of Acquired Mutations and Alternative Splicing of CD19 Enables Resistance to CART-19 Immunotherapy
E Sotillo, DM Barrett, KL Black, A Bagashev, D Oldridge, G Wu, ...
Cancer discovery 5 (12), 1282-1295, 2015
Human chimeric antigen receptor macrophages for cancer immunotherapy
M Klichinsky, M Ruella, O Shestova, XM Lu, A Best, M Zeeman, ...
Nature biotechnology 38 (8), 947-953, 2020
Dual CD19 and CD123 targeting prevents antigen-loss relapses after CD19-directed immunotherapies
M Ruella, DM Barrett, SS Kenderian, O Shestova, TJ Hofmann, ...
The Journal of clinical investigation 126 (10), 3814-3826, 2016
Induction of resistance to chimeric antigen receptor T cell therapy by transduction of a single leukemic B cell
M Ruella, J Xu, DM Barrett, JA Fraietta, TJ Reich, DE Ambrose, ...
Nature medicine 24 (10), 1499-1503, 2018
Preclinical targeting of human acute myeloid leukemia and myeloablation using chimeric antigen receptor–modified T cells
S Gill, SK Tasian, M Ruella, O Shestova, Y Li, DL Porter, M Carroll, ...
Blood, The Journal of the American Society of Hematology 123 (15), 2343-2354, 2014
Ibrutinib enhances chimeric antigen receptor T-cell engraftment and efficacy in leukemia
JA Fraietta, KA Beckwith, PR Patel, M Ruella, Z Zheng, DM Barrett, ...
Blood, The Journal of the American Society of Hematology 127 (9), 1117-1127, 2016
CD33-specific chimeric antigen receptor T cells exhibit potent preclinical activity against human acute myeloid leukemia
SS Kenderian, M Ruella, O Shestova, M Klichinsky, V Aikawa, ...
Leukemia 29 (8), 1637-1647, 2015
Genetic inactivation of CD33 in hematopoietic stem cells to enable CAR T cell immunotherapy for acute myeloid leukemia
MY Kim, KR Yu, SS Kenderian, M Ruella, S Chen, TH Shin, AA Aljanahi, ...
Cell 173 (6), 1439-1453. e19, 2018
Emerging cellular therapies for cancer
S Guedan, M Ruella, CH June
Annual review of immunology 37, 145-171, 2019
Catch me if you can: leukemia escape after CD19-directed T cell immunotherapies
M Ruella, MV Maus
Computational and structural biotechnology journal 14, 357-362, 2016
Pancreatic cancer therapy with combined mesothelin-redirected chimeric antigen receptor T cells and cytokine-armed oncolytic adenoviruses
K Watanabe, Y Luo, T Da, S Guedan, M Ruella, J Scholler, B Keith, ...
JCI insight 3 (7), 2018
Adoptive immunotherapy for cancer
M Ruella, M Kalos
Immunological reviews 257 (1), 14-38, 2014
Impaired death receptor signaling in leukemia causes antigen-independent resistance by inducing CAR T-cell dysfunction
N Singh, YG Lee, O Shestova, P Ravikumar, KE Hayer, SJ Hong, XM Lu, ...
Cancer discovery 10 (4), 552-567, 2020
The Addition of the BTK inhibitor Ibrutinib to anti-CD19 chimeric antigen receptor T cells (CART19) improves responses against mantle cell lymphoma
M Ruella, SS Kenderian, O Shestova, JA Fraietta, S Qayyum, Q Zhang, ...
Clinical Cancer Research 22 (11), 2684-2696, 2016
Optimized depletion of chimeric antigen receptor T cells in murine xenograft models of human acute myeloid leukemia
SK Tasian, SS Kenderian, F Shen, M Ruella, O Shestova, M Kozlowski, ...
Blood, The Journal of the American Society of Hematology 129 (17), 2395-2407, 2017
Overcoming the immunosuppressive tumor microenvironment of Hodgkin lymphoma using chimeric antigen receptor T cells
M Ruella, M Klichinsky, SS Kenderian, O Shestova, A Ziober, DO Kraft, ...
Cancer discovery 7 (10), 1154-1167, 2017
Five-year outcomes for refractory B-cell lymphomas with CAR T-cell therapy
EA Chong, M Ruella, SJ Schuster
New England Journal of Medicine 384 (7), 673-674, 2021
Next-generation chimeric antigen receptor T-cell therapy: going off the shelf
M Ruella, SS Kenderian
BioDrugs 31 (6), 473-481, 2017
An NK-like CAR T cell transition in CAR T cell dysfunction
CR Good, MA Aznar, S Kuramitsu, P Samareh, S Agarwal, G Donahue, ...
Cell 184 (25), 6081-6100. e26, 2021
Immunogenicity of CAR T cells in cancer therapy
DL Wagner, E Fritsche, MA Pulsipher, N Ahmed, M Hamieh, M Hegde, ...
Nature reviews Clinical oncology 18 (6), 379-393, 2021
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