| Massive CA1/2 neuronal loss with intraneuronal and N-terminal truncated Aβ42 accumulation in a novel Alzheimer transgenic model C Casas, N Sergeant, JM Itier, V Blanchard, O Wirths, N Van Der Kolk, ... The American journal of pathology 165 (4), 1289-1300, 2004 | 527 | 2004 |
| Complete OATP1B1 and OATP1B3 deficiency causes human Rotor syndrome by interrupting conjugated bilirubin reuptake into the liver E van de Steeg, V Stránecký, H Hartmannová, L Nosková, M Hřebíček, ... The Journal of clinical investigation 122 (2), 519-528, 2012 | 429 | 2012 |
| Organic anion transporting polypeptide 1a/1b–knockout mice provide insights into hepatic handling of bilirubin, bile acids, and drugs E van de Steeg, E Wagenaar, CMM van der Kruijssen, JEC Burggraaff, ... The Journal of clinical investigation 120 (8), 2010 | 240 | 2010 |
| Human ontogeny of drug transporters: review and recommendations of the pediatric transporter working group KLR Brouwer, LM Aleksunes, B Brandys, GP Giacoia, G Knipp, ... Clinical Pharmacology & Therapeutics 98 (3), 266-287, 2015 | 178 | 2015 |
| Methotrexate pharmacokinetics in transgenic mice with liver-specific expression of human organic anion-transporting polypeptide 1B1 (SLCO1B1) E van de Steeg, CMM van der Kruijssen, E Wagenaar, JEC Burggraaff, ... Drug Metabolism and Disposition 37 (2), 277-281, 2009 | 143 | 2009 |
| Influence of human OATP1B1, OATP1B3, and OATP1A2 on the pharmacokinetics of methotrexate and paclitaxel in humanized transgenic mice E van de Steeg, A van Esch, E Wagenaar, KE Kenworthy, AH Schinkel Clinical cancer research 19 (4), 821-832, 2013 | 128 | 2013 |
| A new approach to predict human intestinal absorption using porcine intestinal tissue and biorelevant matrices J Westerhout, E van de Steeg, D Grossouw, EE Zeijdner, CAM Krul, ... European Journal of Pharmaceutical Sciences 63, 167-177, 2014 | 119 | 2014 |
| Variability in mass spectrometry-based quantification of clinically relevant drug transporters and drug metabolizing enzymes C Wegler, FZ Gaugaz, TB Andersson, JR Wiśniewski, D Busch, C Gröer, ... Molecular pharmaceutics 14 (9), 3142-3151, 2017 | 111 | 2017 |
| Regional expression levels of drug transporters and metabolizing enzymes along the pig and human intestinal tract and comparison with Caco-2 cells SFC Vaessen, MMH van Lipzig, RHH Pieters, CAM Krul, HM Wortelboer, ... Drug metabolism and disposition 45 (4), 353-360, 2017 | 90 | 2017 |
| Functions of OATP1A and 1B transporters in vivo: insights from mouse models D Iusuf, E van de Steeg, AH Schinkel Trends in pharmacological sciences 33 (2), 100-108, 2012 | 89 | 2012 |
| Quantifying phenotypic flexibility as the response to a high‐fat challenge test in different states of metabolic health AFM Kardinaal, MJ van Erk, AE Dutman, JHM Stroeve, E van de Steeg, ... The FASEB Journal 29 (11), 4600-4613, 2015 | 81 | 2015 |
| Predicting carrier-mediated hepatic disposition of rosuvastatin in man by scaling from individual transfected cell-lines in vitro using absolute transporter protein … S Bosgra, E van de Steeg, ML Vlaming, KC Verhoeckx, MT Huisman, ... European Journal of Pharmaceutical Sciences 65, 156-166, 2014 | 73 | 2014 |
| Human OATP1B1, OATP1B3 and OATP1A2 can mediate the in vivo uptake and clearance of docetaxel D Iusuf, JJMA Hendrikx, A van Esch, E van de Steeg, E Wagenaar, ... International journal of cancer 136 (1), 225-233, 2015 | 67 | 2015 |
| High Impact of Oatp1a/1b Transporters on In Vivo Disposition of the Hydrophobic Anticancer Drug Paclitaxel E van de Steeg, A van Esch, E Wagenaar, CMM van der Kruijssen, ... Clinical Cancer Research 17 (2), 294-301, 2011 | 67 | 2011 |
| Drug-drug interactions between rosuvastatin and oral antidiabetic drugs occurring at the level of OATP1B1 E van de Steeg, R Greupink, M Schreurs, IHG Nooijen, KCM Verhoeckx, ... Drug Metabolism and Disposition 41 (3), 592-601, 2013 | 66 | 2013 |
| Species-dependent transport and modulation properties of human and mouse multidrug resistance protein 2 (MRP2/Mrp2, ABCC2/Abcc2) C Zimmermann, K van de Wetering, E van de Steeg, E Wagenaar, C Vens, ... Drug metabolism and disposition 36 (4), 631-640, 2008 | 64 | 2008 |
| Impact of abcc2 [multidrug resistance-associated protein (MRP) 2], abcc3 (MRP3), and abcg2 (breast cancer resistance protein) on the oral pharmacokinetics of methotrexate and … MLH Vlaming, A van Esch, E van de Steeg, Z Pala, E Wagenaar, ... Drug metabolism and disposition 39 (8), 1338-1344, 2011 | 60 | 2011 |
| Organic anion-transporting polypeptide 1B1 mediates transport of Gimatecan and BNP1350 and can be inhibited by several classic ATP-binding cassette (ABC) B1 and/or ABCG2 inhibitors RL Oostendorp, E van de Steeg, CMM van der Kruijssen, JH Beijnen, ... Drug metabolism and disposition 37 (4), 917-923, 2009 | 58 | 2009 |
| Mechanisms and immunomodulatory properties of pre-and probiotics VBM Peters, E Van De Steeg, J Van Bilsen, M Meijerink Beneficial microbes 10 (3), 225-236, 2019 | 54 | 2019 |
| Hepatocyte hopping of OATP1B substrates contributes to efficient hepatic detoxification D Iusuf, E Van De Steeg, AH Schinkel Clinical Pharmacology & Therapeutics 92 (5), 559-562, 2012 | 49 | 2012 |
