|A presenilin dimer at the core of the γ-secretase enzyme: insights from parallel analysis of Notch 1 and APP proteolysis|
EH Schroeter, MXG Ilagan, AL Brunkan, S Hecimovic, Y Li, M Xu, ...
Proceedings of the National Academy of Sciences 100 (22), 13075-13080, 2003
|Phospholipids and Alzheimer’s disease: alterations, mechanisms and potential biomarkers|
M Kosicek, S Hecimovic
International journal of molecular sciences 14 (1), 1310-1322, 2013
|Oxidative stress parameters in plasma of Huntington's disease patients, asymptomatic Huntington’s disease gene carriers and healthy subjects|
N Klepac, M Relja, R Klepac, S Hećimović, T Babić, V Trkulja
Journal of neurology 254 (12), 1676-1683, 2007
|The low density lipoprotein receptor-related protein 1B retains β-amyloid precursor protein at the cell surface and reduces amyloid-β peptide production|
JA Cam, CV Zerbinatti, JM Knisely, S Hecimovic, Y Li, G Bu
Journal of Biological Chemistry 279 (28), 29639-29646, 2004
|Mutations in APP have independent effects on Aβ and CTFγ generation|
S Hecimovic, J Wang, G Dolios, M Martinez, R Wang, AM Goate
Neurobiology of disease 17 (2), 205-218, 2004
|Cholesterol accumulation in Niemann Pick type C (NPC) model cells causes a shift in APP localization to lipid rafts|
M Kosicek, M Malnar, A Goate, S Hecimovic
Biochemical and biophysical research communications 393 (3), 404-409, 2010
|Conserved “PAL” sequence in presenilins is essential for γ-secretase activity, but not required for formation or stabilization of γ-secretase complexes|
J Wang, AL Brunkan, S Hecimovic, E Walker, A Goate
Neurobiology of disease 15 (3), 654-666, 2004
|Elevated cerebrospinal fluid sphingomyelin levels in prodromal Alzheimer's disease|
M Kosicek, H Zetterberg, N Andreasen, J Peter-Katalinic, S Hecimovic
Neuroscience letters 516 (2), 302-305, 2012
|Bidirectional links between Alzheimer's disease and Niemann–Pick type C disease|
M Malnar, S Hecimovic, N Mattsson, H Zetterberg
Neurobiology of disease 72, 37-47, 2014
|Nano-HPLC–MS analysis of phospholipids in cerebrospinal fluid of Alzheimer’s disease patients—a pilot study|
M Kosicek, S Kirsch, R Bene, Z Trkanjec, M Titlic, L Bindila, ...
Analytical and bioanalytical chemistry 398 (7), 2929-2937, 2010
|Expand long PCR for fragile X mutation detection|
S Hećimović, I Barišić, A Müller, I Petković, I Barić, I Ligutić, K Pavelić
Clinical genetics 52 (3), 147-154, 1997
|Loss of cathepsin B and L leads to lysosomal dysfunction, NPC-like cholesterol sequestration and accumulation of the key Alzheimer's proteins|
S Cermak, M Kosicek, A Mladenovic-Djordjevic, K Smiljanic, S Kanazir, ...
PLoS One 11 (11), e0167428, 2016
|Niemann–Pick type C cells show cholesterol dependent decrease of APP expression at the cell surface and its increased processing through the β-secretase pathway|
M Malnar, M Kosicek, S Mitterreiter, D Omerbasic, SF Lichtenthaler, ...
Biochimica et Biophysica Acta (BBA)-Molecular Basis of Disease 1802 (7-8 …, 2010
|Cholesterol-depletion corrects APP and BACE1 misstrafficking in NPC1-deficient cells|
M Malnar, M Kosicek, A Lisica, M Posavec, A Krolo, J Njavro, ...
Biochimica et Biophysica Acta (BBA)-Molecular Basis of Disease 1822 (8 …, 2012
|Amyloid-β metabolism in Niemann-Pick C disease models and patients|
N Mattsson, M Olsson, MK Gustavsson, M Kosicek, M Malnar, ...
Metabolic brain disease 27 (4), 573-585, 2012
|Biochemical, neuropathological, and neuroimaging characteristics of early-onset Alzheimer's disease due to a novel PSEN1 mutation|
JM Ringman, KH Gylys, LD Medina, M Fox, V Kepe, DL Flores, ...
Neuroscience letters 487 (3), 287-292, 2011
|Genetic background of huntington disease in Croatia: molecular analysis of CAG, CCG, and Δ2642 (E2642del) polymorphisms|
S Hećimović, N Klepac, J Vlašić, A Vojta, D Janko, I Škarpa‐Prpić, ...
Human mutation 20 (3), 233-233, 2002
|Characterization of N-terminal processing of group VIA phospholipase A2 and of potential cleavage sites of amyloid precursor protein constructs by automated …|
H Song, S Hecimovic, A Goate, FF Hsu, S Bao, I Vidavsky, ...
Journal of the American Society for Mass Spectrometry 15 (12), 1780-1793, 2004
|N-glycome of the lysosomal glycocalyx is altered in Niemann-Pick type C disease (NPC) model cells|
M Kosicek, I Gudelj, A Horvatic, T Jovic, F Vuckovic, G Lauc, S Hecimovic
Molecular & Cellular Proteomics 17 (4), 631-642, 2018
|Novel amino-β-lactam derivatives as potent cholesterol absorption inhibitors|
KD Dražić T, Molčanov K, Sachdev V, Malnar M, Hecimovic S, Patankar JV ...
European Journal of Medicinal Chemistry 87, 722-734, 2014