Emergent properties of networks of biological signaling pathways US Bhalla, R Iyengar Science 283 (5400), 381-387, 1999 | 2016 | 1999 |
G protein pathways SR Neves, PT Ram, R Iyengar Science 296 (5573), 1636-1639, 2002 | 1465 | 2002 |
Functional atlas of the integrin adhesome R Zaidel-Bar, S Itzkovitz, A Ma'ayan, R Iyengar, B Geiger Nature cell biology 9 (8), 858-867, 2007 | 1321 | 2007 |
Complexity in biological signaling systems G Weng, US Bhalla, R Iyengar Science 284 (5411), 92-96, 1999 | 829 | 1999 |
MAP kinase phosphatase as a locus of flexibility in a mitogen-activated protein kinase signaling network US Bhalla, PT Ram, R Iyengar Science 297 (5583), 1018-1023, 2002 | 742 | 2002 |
Molecular basis for interactions of G protein βγ subunits with effectors CE Ford, NP Skiba, H Bae, Y Daaka, E Reuveny, LR Shekter, R Rosal, ... Science 280 (5367), 1271-1274, 1998 | 547 | 1998 |
Signaling networks: the origins of cellular multitasking JD Jordan, EM Landau, R Iyengar Cell 103 (2), 193-200, 2000 | 529 | 2000 |
Gating of CaMKII by cAMP-regulated protein phosphatase activity during LTP RD Blitzer, JH Connor, GP Brown, T Wong, S Shenolikar, R Iyengar, ... Science 280 (5371), 1940-1943, 1998 | 511 | 1998 |
Network analyses in systems pharmacology SI Berger, R Iyengar Bioinformatics 25 (19), 2466-2472, 2009 | 433 | 2009 |
Mutation of SHOC2 promotes aberrant protein N-myristoylation and causes Noonan-like syndrome with loose anagen hair V Cordeddu, E Di Schiavi, LA Pennacchio, A Ma'ayan, A Sarkozy, ... Nature genetics 41 (9), 1022-1026, 2009 | 405 | 2009 |
Molecular and functional diversity of mammalian Gs‐stimulated adenylyl cyclases R Iyengar The FASEB Journal 7 (9), 768-775, 1993 | 404 | 1993 |
The G protein-gated atrial K+ channel is stimulated by three distinct Giα-subunits A Yatani, R Mattera, J Codina, R Graf, K Okabe, E Padrell, R Iyengar, ... Nature 336 (6200), 680-682, 1988 | 404 | 1988 |
Stimulation and inhibition of adenylyl cyclases mediated by distinct regulatory proteins JD Hildebrandt, RD Sekura, J Codina, R Iyengar, CR Manclark, ... Nature 302 (5910), 706-709, 1983 | 382 | 1983 |
Formation of regulatory patterns during signal propagation in a mammalian cellular network A Ma'ayan, SL Jenkins, S Neves, A Hasseldine, E Grace, B Dubin-Thaler, ... Science 309 (5737), 1078-1083, 2005 | 377 | 2005 |
Postsynaptic cAMP pathway gates early LTP in hippocampal CA1 region RD Blitzer, T Wong, R Nouranifar, R Iyengar, EM Landau Neuron 15 (6), 1403-1414, 1995 | 354 | 1995 |
Systems approaches to polypharmacology and drug discovery ADW Boran, R Iyengar Current opinion in drug discovery & development 13 (3), 297, 2010 | 328 | 2010 |
Pertussis toxin substrate, the putative Ni component of adenylyl cyclases, is an alpha beta heterodimer regulated by guanine nucleotide and magnesium. J Codina, J Hildebrandt, R Iyengar, L Birnbaumer, RD Sekura, ... Proceedings of the National Academy of Sciences 80 (14), 4276-4280, 1983 | 326 | 1983 |
Systems pharmacology: network analysis to identify multiscale mechanisms of drug action S Zhao, R Iyengar Annual review of pharmacology and toxicology 52, 505, 2012 | 317 | 2012 |
A region of adenylyl cyclase 2 critical for regulation by G protein βγ subunits J Chen, M DeVivo, J Dingus, A Harry, J Li, J Sui, DJ Carty, JL Blank, ... Science 268 (5214), 1166-1169, 1995 | 312 | 1995 |
Cell shape and negative links in regulatory motifs together control spatial information flow in signaling networks SR Neves, P Tsokas, A Sarkar, EA Grace, P Rangamani, SM Taubenfeld, ... Cell 133 (4), 666-680, 2008 | 310 | 2008 |