Prati
Andreas Kraemer
Andreas Kraemer
Group Leader, Structural Genomics Consortium
Potvrđena adresa e-pošte na pharmchem.uni-frankfurt.de
Naslov
Citirano
Citirano
Godina
A chemical toolbox for the study of bromodomains and epigenetic signaling
Q Wu, D Heidenreich, S Zhou, S Ackloo, A Krämer, K Nakka, ...
Nature communications 10 (1), 1915, 2019
1202019
Toward photopharmacological antimicrobial chemotherapy using photoswitchable amidohydrolase inhibitors
CE Weston, A Krämer, F Colin, O Yildiz, MGJ Baud, FJ Meyer-Almes, ...
ACS Infectious Diseases 3 (2), 152-161, 2017
902017
Exploiting vulnerabilities of SWI/SNF chromatin remodelling complexes for cancer therapy
M Wanior, A Krämer, S Knapp, AC Joerger
Oncogene 40 (21), 3637-3654, 2021
862021
Development of a potent and selective chemical probe for the pleiotropic kinase CK2
CI Wells, DH Drewry, JE Pickett, A Tjaden, A Krämer, S Müller, L Gyenis, ...
Cell chemical biology 28 (4), 546-558. e10, 2021
732021
Targeting cavity-creating p53 cancer mutations with small-molecule stabilizers: the Y220X paradigm
MR Bauer, A Krämer, G Settanni, RN Jones, X Ni, R Khan Tareque, ...
ACS Chemical Biology 15 (3), 657-668, 2020
572020
Design, synthesis, and evaluation of WD-repeat-containing protein 5 (WDR5) degraders
A Dölle, B Adhikari, A Krämer, J Weckesser, N Berner, LM Berger, ...
Journal of medicinal chemistry 64 (15), 10682-10710, 2021
522021
Pharmacological targeting of MTHFD2 suppresses acute myeloid leukemia by inducing thymidine depletion and replication stress
N Bonagas, NMS Gustafsson, M Henriksson, P Marttila, R Gustafsson, ...
Nature cancer 3 (2), 156-172, 2022
402022
Optimization of pyrazolo [1, 5-a] pyrimidines lead to the identification of a highly selective casein kinase 2 inhibitor
A Krämer, CG Kurz, BT Berger, IE Celik, A Tjaden, FA Greco, S Knapp, ...
European journal of medicinal chemistry 208, 112770, 2020
322020
Substrate specificity and function of acetylpolyamine amidohydrolases from Pseudomonas aeruginosa
A Krämer, J Herzer, J Overhage, FJ Meyer-Almes
BMC biochemistry 17, 1-10, 2016
252016
Tracking the PROTAC degradation pathway in living cells highlights the importance of ternary complex measurement for PROTAC optimization
MP Schwalm, A Krämer, A Dölle, J Weckesser, X Yu, J Jin, K Saxena, ...
Cell chemical biology 30 (7), 753-765. e8, 2023
242023
Pan-SMARCA/PB1 bromodomain inhibitors and their role in regulating adipogenesis
M Wanior, F Preuss, X Ni, A Krämer, S Mathea, T Göbel, ...
Journal of medicinal chemistry 63 (23), 14680-14699, 2020
242020
A fluorescence lifetime-based binding assay for acetylpolyamine amidohydrolases from Pseudomonas aeruginosa using a [1,3]dioxolo[4,5-f][1,3]benzodioxole …
C Meyners, R Wawrzinek, A Krämer, S Hinz, P Wessig, FJ Meyer-Almes
Analytical and bioanalytical chemistry 406, 4889-4897, 2014
222014
Discovery of Highly Selective Inhibitors of Calmodulin-Dependent Kinases That Restore Insulin Sensitivity in the Diet-Induced Obesity in Vivo Mouse Model
C Fromont, A Atzori, D Kaur, L Hashmi, G Greco, A Cabanillas, ...
Journal of medicinal chemistry 63 (13), 6784-6801, 2020
182020
Development of a chemical probe against NUDT15
SM Zhang, M Desroses, A Hagenkort, NCK Valerie, D Rehling, M Carter, ...
Nature chemical biology 16 (10), 1120-1128, 2020
172020
Covalent inhibition of histone deacetylase 8 by 3, 4-dihydro-2H-pyrimido [1, 2-c][1, 3] benzothiazin-6-imine
M Muth, N Jänsch, A Kopranovic, A Krämer, N Wössner, M Jung, ...
Biochimica et Biophysica Acta (BBA)-General Subjects 1863 (3), 577-585, 2019
152019
Selective targeting of the αC and DFG-out pocket in p38 MAPK
S Roehm, M Schroeder, JE Dwyer, CS Widdowson, A Chaikuad, ...
European Journal of Medicinal Chemistry 208, 112721, 2020
142020
Structure of a glutamine donor mimicking inhibitory peptide shaped by the catalytic cleft of microbial transglutaminase
NE Juettner, S Schmelz, A Kraemer, S Knapp, B Becker, H Kolmar, ...
The FEBS journal 285 (24), 4684-4694, 2018
132018
Illuminating the Dark: Highly Selective Inhibition of Serine/Threonine Kinase 17A with Pyrazolo[1,5-a]pyrimidine-Based Macrocycles
CG Kurz, F Preuss, A Tjaden, M Cusack, JA Amrhein, D Chatterjee, ...
Journal of Medicinal Chemistry 65 (11), 7799-7817, 2022
112022
Chemistry-led investigations into the mode of action of NAMPT activators, resulting in the discovery of non-pyridyl class NAMPT activators
S Tang, MG Sanz, O Smith, A Krämer, D Egbase, PW Caton, S Knapp, ...
Acta Pharmaceutica Sinica B 13 (2), 709-721, 2023
102023
Macrocyclization of quinazoline-based EGFR inhibitors leads to exclusive mutant selectivity for EGFR L858R and Del19
JA Amrhein, TS Beyett, WW Feng, A Krämer, J Weckesser, IK Schaeffner, ...
Journal of medicinal chemistry 65 (23), 15679-15697, 2022
102022
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