Paul Leeson
Paul Leeson
Paul Leeson Consulting Ltd
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The influence of drug-like concepts on decision-making in medicinal chemistry
PD Leeson, B Springthorpe
Nature reviews Drug discovery 6 (11), 881-890, 2007
An analysis of the attrition of drug candidates from four major pharmaceutical companies
MJ Waring, J Arrowsmith, AR Leach, PD Leeson, S Mandrell, RM Owen, ...
Nature reviews Drug discovery 14 (7), 475-486, 2015
Is there a difference between leads and drugs? A historical perspective
TI Oprea, AM Davis, SJ Teague, PD Leeson
Journal of chemical information and computer sciences 41 (5), 1308-1315, 2001
The design of leadlike combinatorial libraries
SJ Teague, AM Davis, PD Leeson, T Oprea
Angewandte Chemie International Edition 38 (24), 3743-3748, 1999
The role of ligand efficiency metrics in drug discovery
AL Hopkins, GM Keserü, PD Leeson, DC Rees, CH Reynolds
Nature reviews Drug discovery 13 (2), 105-121, 2014
7-Chlorokynurenic acid is a selective antagonist at the glycine modulatory site of the N-methyl-D-aspartate receptor complex.
JA Kemp, AC Foster, PD Leeson, T Priestley, R Tridgett, LL Iversen, ...
Proceedings of the National Academy of Sciences 85 (17), 6547-6550, 1988
A comparison of physiochemical property profiles of development and marketed oral drugs
MC Wenlock, RP Austin, P Barton, AM Davis, PD Leeson
Journal of medicinal chemistry 46 (7), 1250-1256, 2003
The glycine site of the NMDA receptor—five years on
JA Kemp, PD Leeson
Trends in Pharmacological Sciences 14 (1), 20-25, 1993
The glycine site on the NMDA receptor: structure-activity relationships and therapeutic potential
PD Leeson, LL Iversen
Journal of medicinal chemistry 37 (24), 4053-4067, 1994
Chemical beauty contest
P Leeson
Nature 481 (7382), 455-456, 2012
3-[[4-(4-Chlorophenyl) piperazin-1-yl] methyl]-1 H-pyrrolo [2, 3-b] pyridine: An Antagonist with High Affinity and Selectivity for the Human Dopamine D4 Receptor
JJ Kulagowski, HB Broughton, NR Curtis, IM Mawer, MP Ridgill, R Baker, ...
Journal of medicinal chemistry 39 (10), 1941-1942, 1996
Time-related differences in the physical property profiles of oral drugs
PD Leeson, AM Davis
Journal of medicinal chemistry 47 (25), 6338-6348, 2004
From ATP to AZD6140: the discovery of an orally active reversible P2Y12 receptor antagonist for the prevention of thrombosis
B Springthorpe, A Bailey, P Barton, TN Birkinshaw, RV Bonnert, ...
Bioorganic & medicinal chemistry letters 17 (21), 6013-6018, 2007
4-Amido-2-carboxytetrahydroquinolines. Structure-activity relationships for antagonism at the glycine site of the NMDA receptor
PD Leeson, RW Carling, KW Moore, AM Moseley, JD Smith, G Stevenson, ...
Journal of medicinal chemistry 35 (11), 1954-1968, 2002
[3H] L-655,708, a novel ligand selective for the benzodiazepine site of GABAA receptors which contain the α5 subunit
K Quirk, P Blurton, S Fletcher, P Leeson, F Tang, D Mellilo, CI Ragan, ...
Neuropharmacology 35 (9-10), 1331-1335, 1996
Kynurenic acid derivatives. Structure-activity relationships for excitatory amino acid antagonism and identification of potent and selective antagonists at the glycine site on …
PD Leeson, R Baker, RW Carling, NR Curtis, KW Moore, BJ Williams, ...
Journal of medicinal chemistry 34 (4), 1243-1252, 1991
Biological profile of L-745,870, a selective antagonist with high affinity for the dopamine D4 receptor
S Patel, S Freedman, KL Chapman, F Emms, AE Fletcher, M Knowles, ...
Journal of Pharmacology and Experimental Therapeutics 283 (2), 636-647, 1997
3-Phenyl-6-(2-pyridyl)methyloxy-1,2,4-triazolo[3,4-a]phthalazines and Analogues:  High-Affinity γ-Aminobutyric Acid-A Benzodiazepine Receptor Ligands with α2 …
RW Carling, KW Moore, LJ Street, D Wild, C Isted, PD Leeson, S Thomas, ...
Journal of Medicinal Chemistry 47 (7), 1807-1822, 2004
Enantiomers of HA-966 (3-amino-1-hydroxypyrrolid-2-one) exhibit distinct central nervous system effects:(+)-HA-966 is a selective glycine/N-methyl-D-aspartate receptor …
L Singh, AE Donald, AC Foster, PH Hutson, LL Iversen, SD Iversen, ...
Proceedings of the National Academy of Sciences 87 (1), 347-351, 1990
Effect of plasma protein binding on in vivo activity and brain penetration of glycine/NMDA receptor antagonists
M Rowley, JJ Kulagowski, AP Watt, D Rathbone, GI Stevenson, ...
Journal of medicinal chemistry 40 (25), 4053-4068, 1997
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