| ABCA1 is required for normal central nervous system ApoE levels and for lipidation of astrocyte-secreted apoE SE Wahrle, H Jiang, M Parsadanian, J Legleiter, X Han, JD Fryer, ... Journal of Biological Chemistry 279 (39), 40987-40993, 2004 | 676 | 2004 |
| Accelerating amyloid-β fibrillization reduces oligomer levels and functional deficits in Alzheimer disease mouse models IH Cheng, K Scearce-Levie, J Legleiter, JJ Palop, H Gerstein, N Bien-Ly, ... Journal of Biological Chemistry 282 (33), 23818-23828, 2007 | 479 | 2007 |
| Green tea (−)-epigallocatechin-gallate modulates early events in huntingtin misfolding and reduces toxicity in Huntington's disease models DE Ehrnhoefer, M Duennwald, P Markovic, JL Wacker, S Engemann, ... Human molecular genetics 15 (18), 2743-2751, 2006 | 442 | 2006 |
| Structure of gel phase DMPC determined by X-ray diffraction S Tristram-Nagle, Y Liu, J Legleiter, JF Nagle Biophysical journal 83 (6), 3324-3335, 2002 | 405 | 2002 |
| Mutant huntingtin fragments form oligomers in a polyglutamine length-dependent manner in vitro and in vivo J Legleiter, E Mitchell, GP Lotz, E Sapp, C Ng, M DiFiglia, LM Thompson, ... Journal of Biological Chemistry 285 (19), 14777-14790, 2010 | 232 | 2010 |
| Identifying polyglutamine protein species in situ that best predict neurodegeneration J Miller, M Arrasate, E Brooks, CP Libeu, J Legleiter, D Hatters, J Curtis, ... Nature chemical biology 7 (12), 925-934, 2011 | 217 | 2011 |
| Effect of different anti-Aβ antibodies on Aβ fibrillogenesis as assessed by atomic force microscopy J Legleiter, DL Czilli, B Gitter, RB DeMattos, DM Holtzman, T Kowalewski Journal of molecular biology 335 (4), 997-1006, 2004 | 187 | 2004 |
| Scanning probe acceleration microscopy (SPAM) in fluids: mapping mechanical properties of surfaces at the nanoscale J Legleiter, M Park, B Cusick, T Kowalewski Proceedings of the National Academy of Sciences 103 (13), 4813-4818, 2006 | 168 | 2006 |
| Identical oligomeric and fibrillar structures captured from the brains of R6/2 and knock-in mouse models of Huntington's disease K Sathasivam, A Lane, J Legleiter, A Warley, B Woodman, S Finkbeiner, ... Human molecular genetics 19 (1), 65-78, 2010 | 166 | 2010 |
| Collagen VI protects neurons against Aβ toxicity JS Cheng, DB Dubal, DH Kim, J Legleiter, IH Cheng, GQ Yu, I Tesseur, ... Nature neuroscience 12 (2), 119-121, 2009 | 138 | 2009 |
| Identification of novel potentially toxic oligomers formed in vitro from mammalian-derived expanded huntingtin exon-1 protein LG Nucifora, KA Burke, X Feng, N Arbez, S Zhu, J Miller, G Yang, ... Journal of Biological Chemistry 287 (19), 16017-16028, 2012 | 123 | 2012 |
| Proteins containing expanded polyglutamine tracts and neurodegenerative disease A Adegbuyiro, F Sedighi, AW Pilkington IV, S Groover, J Legleiter Biochemistry 56 (9), 1199-1217, 2017 | 122 | 2017 |
| Biophysical insights into how surfaces, including lipid membranes, modulate protein aggregation related to neurodegeneration KA Burke, EA Yates, J Legleiter Frontiers in neurology 4, 17, 2013 | 113 | 2013 |
| Monoclonal antibodies recognize distinct conformational epitopes formed by polyglutamine in a mutant huntingtin fragment J Legleiter, GP Lotz, J Miller, J Ko, C Ng, GL Williams, S Finkbeiner, ... Journal of Biological Chemistry 284 (32), 21647-21658, 2009 | 111 | 2009 |
| Hsp70 and Hsp40 functionally interact with soluble mutant huntingtin oligomers in a classic ATP-dependent reaction cycle GP Lotz, J Legleiter, R Aron, EJ Mitchell, SY Huang, C Ng, C Glabe, ... Journal of Biological Chemistry 285 (49), 38183-38193, 2010 | 94 | 2010 |
| The interaction of polyglutamine peptides with lipid membranes is regulated by flanking sequences associated with huntingtin KA Burke, KJ Kauffman, CS Umbaugh, SL Frey, J Legleiter Journal of Biological Chemistry 288 (21), 14993-15005, 2013 | 90 | 2013 |
| Solid-state NMR study of cysteine on gold nanoparticles A Abraham, E Mihaliuk, B Kumar, J Legleiter, T Gullion The Journal of Physical Chemistry C 114 (42), 18109-18114, 2010 | 68 | 2010 |
| Huntingtin disrupts lipid bilayers in a polyQ-length dependent manner KA Burke, KM Hensal, CS Umbaugh, M Chaibva, J Legleiter Biochimica et Biophysica Acta (BBA)-Biomembranes 1828 (8), 1953-1961, 2013 | 66 | 2013 |
| The emerging role of the first 17 amino acids of huntingtin in Huntington’s disease JR Arndt, M Chaibva, J Legleiter Biomolecular concepts 6 (1), 33-46, 2015 | 61 | 2015 |
| Acetylation within the first 17 residues of huntingtin exon 1 alters aggregation and lipid binding M Chaibva, S Jawahery, AW Pilkington, JR Arndt, O Sarver, S Valentine, ... Biophysical journal 111 (2), 349-362, 2016 | 58 | 2016 |
